Missed Dose .

1976451-overview Baseline fosfomycin susceptibility of test isolates. 2020 Jul 1;75(7):1879-1888. doi: 10.1093/jac/dkaa127.Drugs. Shown are data for simulations of three 3-g oral doses of fosfomycin administered every 72 h (A), 48 h (B), and 24 h (C).
We therefore performed pharmacodynamic profiling of oral fosfomycin, using a dynamic bladder infection in vitro model, to assess high and low urinary exposures following a single oral dose and three repeat doses given every 72 h, 48 h, and 24 h against 16 clinical isolates with various MICs of fosfomycin (8 Escherichia coli, 4 Enterobacter cloacae, and 4 Klebsiella pneumoniae isolates). Drugs News

Fosfomycin was administered as a single dose, simulating an oral 3-g dose with average exposure (A), low urinary Multidose fosfomycin urinary concentrations.
The impact of interindividual variability in urinary concentrations on antimicrobial efficacy, and any benefit of giving multiple doses, is uncertain.

informational and educational purposes only. Shown are data for three simulated 3-g oral doses of fosfomycin given every 72 h (A), 48 h (B), and 24 h (C).

If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible. Multi-drug resistant UTI: 2-3 g PO every 2-3 days for 3 dosesPreparation: Dissolve 1 packet (3 g) in 3-4 oz water3 g PO q2-3 days or 3 g PO qDay for 1 week followed by 3 g q48hr for ≥6 weeksNot indicated for the treatment of perinephric abscess or pyelonephritisConsider alternative agents if bacteriuria persists or reappearsHepatic injury, including hepatitis and steatosis reported; monitor liver function; effect is reversible upon discontinuation of drugProlonged use may result in bacterial or fungal superinfections, which may appear upt to two months postantibiotic treatmentHypersensitivity reactions, including anaphylactic shock reported; discontinue use at first signs of hypersensitivity reactions and institute supportive measuresLactation: excreted in breast milk; not recommendedA: Generally acceptable. 2002

Do not double doses. HighWire

Online ahead of print.Abbott IJ, van Gorp E, van der Meijden A, Wijma RA, Meletiadis J, Roberts JA, Mouton JW, Peleg AY.Antimicrob Agents Chemother. This website also contains material copyrighted by 3rd parties.

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Clipboard, Search History, and several other advanced features are temporarily unavailable. Shown are data for simulated 3-g… Growth outcome following multiple fosfomycin doses.

Unable to load your delegates due to an error Please enable it to take advantage of the complete set of features! This site needs JavaScript to work properly. If you log out, you will be required to enter your username and password the next time you visit. Free PMC article Oral fosfomycin is FDA approved at a single 3-g dose to treat uncomplicated urinary tract infection (UTI) (ie, acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis. Total growth and high-level-resistant (HLR) growth are presented for all 16 isolates: 8 E. coli isolates, 4 E. cloacae isolates, and 4 K. pneumoniae isolates. Storage Shown… Multidose fosfomycin urinary concentrations.

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