Oral presentations include solution and tablets.The studies of intrapulmonary pharmacokinetics of linezolid show that the drug accumulates in epithelial cells (linezolid plasma and lung epithelial lining fluid concentrations were 15.5 and 64.3 mg/L, respectively, 4 h after the dose). Concentrations of linezolid in alveolar cells did not exceed 2.2 mg/L at any measurement point.Tissue penetration is considered excellent in skin, soft tissue, lung, heart, intestine, liver, urine, kidney and CSF. Its mechanism of action is unique (early inhibition of the protein synthesis), so no cross‐resistance with other anti‐Gram‐positive drugs is expected. Linezolid should not be administered to patients with the following underlying clinical conditions or on the following types of concomitant medications unless there are facilities available for close observation of the patient and monitoring of blood pressure.1 Patients with uncontrolled hypertension, phaeochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizo‐affective disorder, acute confusional states.2 Patients taking any of the following medications: Serotonin re‐uptake inhibitors, tricyclic antidepressants, directly‐ and indirectly‐acting sympathomimetic agents (including the adrenergic bronchodilators, pseudoephedrine and phenylpropanolamine), vasopressive agents, dopaminergic agents, pethidine or buspirone.The total daily cost of linezolid at the usual dose of 600 mg per 12 h is approximately $137 for the IV presentation and of $87 for the oral therapy [Please check your email for instructions on resetting your password. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username

There are no data regarding its presence in breast milk, placental transfer and transfer to fetus.The recommended dosage of linezolid (IV or oral) is 600 mg every 12 h. As mentioned, the drug may be given intravenously or orally or switched from the parenteral route to the oral route when the severity of the disease subsides.In patients with uncomplicated SSTIs the recommended dosage of linezolid is 400 mg/12 h [Patient age or sex did not significantly influence the pharmacokinetic properties of oral linezolid.

Store at room temperature / Protect from light / Do not freeze. Fifty percent of a linezolid dose is metabolized in the liver to 2 inactive metabolites, and 30% of the dose is excreted in the urine as unchanged drug. phenelzine, isocarboxacid, selegiline, moclobemide) or within 2 weeks of taking any such drug.

However, when patients with missing or indeterminate outcome were excluded, linezolid showed a higher rate of clinical success in patients whom it was possible to evaluate: 94% (97 of 103 patients) vs. 87% (96 of 110 patients) for vancomycin.

AUC24/MIC is the most reliable predictor of antimicrobial (vancomycin, linezolid, tetracyclines, azithromycin) ... in patients with renal failure and hepatic failure are showed in Tables Tables5 5 and and6 6. Search for other works by this author on:

There is no adjustment recommended for patients with renal failure; however, linezolid clearance is increased by 80% during intermittent hemodialysis.

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