(Note: Data described in Table 1 below are pooled from studies with variable designs and safety evaluations. Since Tinidazole crosses the placental barrier and enters the fetal circulation, it should not be administered to pregnant patients in the first trimester.Toxicity studies of embryo-fetal development in pregnant mice indicated embryo-fetal toxicity or malformations at the highest dose level of 2,500 mg (approximately 6.3 times the highest human therapeutic dose based on conversions of body surface area).In a study with pregnant rats, a slightly higher incidence of fetal mortality was observed at a maternal dose of 500 mg (2.5 times the highest human therapeutic dose based on conversions of body surface area).No biologically relevant neonatal development effects were observed in rat neonates after maternal doses as high as 600 mg (the human therapeutic dose 3 times higher than the body surface area conversions).Tinidazole is excreted in breast milk in concentrations similar to those observed in serum. Tinidazole is a synthetic Antiprotozoal agent. Inactive ingredients include pregelatinized starch NF, croscarmellose sodium NF, magnesium stearate NF, microcrystalline cellulose NF, polyvinyl alcohol-part hydrolyzed USP, titanium dioxide USP, polyethylene glycol 3000 NF, talc USP, and FD&C red # 40 aluminum lake.Administration of Tinidazole Tablets with food did not affect AUC or TIn healthy volunteers, administration of crushed Tinidazole Tablets in artificial cherry syrup, [prepared as described in Tinidazole is biotransformed mainly by CYP3A4. It shows activity both in vitro and in clinical infections against the following protozoa: Trichomonas Vaginalis, Giardia duodenalis (also called G. lamblia) and Entamoeba histolytica. It does not seem to have activity against most strains of vaginal lactobacilli. Since tinidazole crosses the placental barrier and enters fetal circulation it should not be administered to pregnant patients in the first trimester.Embryo-fetal developmental toxicity studies in pregnant mice indicated no embryo-fetal toxicity or malformations at the highest dose level of 2,500 mg/kg (approximately 6.3-fold the highest human therapeutic dose based upon body surface area conversions). Tell your doctor about the allergy and what signs you had. Mechanism of Action of tinidazole The mode of action of tinidazole against anaerobic bacteria and protozoa involves penetration of the drug into the cell of the microorganisms. Once inside the cell, it undergoes intracellular chemical reduction during anaerobic metabolism. In an The potential of tinidazole to induce the metabolism of other drugs has not been evaluated.Tinidazole does not appear to have activity against most strains of vaginal lactobacilli.For protozoal parasites, standardized susceptibility tests do not exist for use in clinical microbiology laboratories.of Tinidazole Tablets with food resulted in a delay in TIn a 60-day fertility study, tinidazole reduced fertility and produced testicular histopathology in male rats at a 600 mg/kg/day dose level (approximately 3-fold the highest human therapeutic dose based upon body surface area conversions). She specializes in family medicine.ScopeHeal uses Google Adsense, a Web-advertising-service of Google Inc., the United States (“Google”). If you are allergic to tinidazole; any part of tinidazole; or any other drugs, foods, or substances. However, you can start breastfeeding again 3 days after taking the last dose.If you use a breast pump during your treatment, throw out the milk you collect while taking Tinidazole. Common (≥ 1% incidence) adverse reactions reported by body system are as follows. Tinidazole is a synthetic Antiprotozoal agent. Your symptoms may improve before the infection has completely disappeared. Mechanism of Action of Tinidazole Tinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. In a study with pregnant rats a slightly higher incidence of fetal mortality was observed at a maternal dose of 500 mg/kg (2.5-fold the highest human therapeutic dose based upon body surface area conversions). )Central Nervous System: Two serious adverse reactions reported include convulsions and transient peripheral neuropathy including numbness and paresthesia Gastrointestinal: tongue discoloration, stomatitis, diarrheaHypersensitivity: urticaria, pruritis, rash, flushing, sweating, dryness of mouth, fever, burning sensation, thirst, salivation, angioedemaHematopoietic: transient neutropenia, transient leukopeniaSevere acute hypersensitivity reactions have been reported on initial or subsequent exposure to tinidazole.

Do not take additional medications to make up for the forgotten dose.Tinidazole crosses the placental barrier and is secreted in breast milk. Talk to your doctor about your individual risk.To make sure you can safely take Tinidazole, tell your doctor if you have any of these other conditions:Dr. Cameron Troup,, MD is a family medicine specialist in Eastchester, NY and has been practicing for 25 years.

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