Management: Concurrent use of aspirin at doses beyond cardioprotective levels is not recommended.

If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects).Dacomitinib: Proton Pump Inhibitors may decrease the serum concentration of Dacomitinib.

This medicine is available only with your doctor's prescription. An increased risk of bleeding may occur.

Alcohol (Ethyl): May enhance the adverse/toxic effect of Aspirin. These data are derived from studies with Ritonavir-boosted Tipranavir.Tipranavir: May enhance the antiplatelet effect of Agents with Antiplatelet Properties.Tricyclic Antidepressants (Tertiary Amine): May enhance the antiplatelet effect of Aspirin.Urokinase: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Urokinase.

Discontinue therapy if signs or symptoms of CLE or SLE occur and refer to specialist for evaluation; most patients improve 4 to 12 weeks after discontinuation of omeprazole.• Fractures: Increased incidence of osteoporosis-related bone fractures of the hip, spine, or wrist may occur with PPI therapy. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Yosprala: Aspirin 81 mg and omeprazole 40 mg, Aspirin 325 mg and omeprazole 40 mg [contains corn starch, fd&c blue #2 (indigotine)]Generic: Aspirin 325 mg and omeprazole 40 mg, Aspirin 81 mg and omeprazole 40 mgAspirin: Irreversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, via acetylation, which results in decreased formation of prostaglandin precursors; irreversibly inhibits formation of prostaglandin derivative, thromboxane A2, via acetylation of platelet cyclooxygenase, thus inhibiting platelet aggregation; has antipyretic, analgesic, and anti-inflammatory properties.Omeprazole: Suppresses gastric basal and stimulated acid secretion by inhibiting the parietal cell H+/K+ ATP pumpLimitations of use: Not for use as the initial dose of aspirin therapy during onset of acute coronary syndrome, acute myocardial infarction or before percutaneous coronary intervention; has not been shown to reduce the risk of gastrointestinal bleeding due to aspirin.Hypersensitivity to aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), omeprazole, other substituted benzimidazole proton pump inhibitors, or to any component of the formulation; history of asthma, urticaria, rhinitis, and nasal polyps or other allergic-type reactions after taking aspirin or other NSAIDs; pediatric patients with suspected viral infections, with or without fever; concurrent use with rilpivirine-containing products.Documentation of allergenic cross-reactivity for salicylates is limited.

Objectives In 2009, the FDA issued a warning that omeprazole–a proton pump inhibitor (PPI)–reduces the antithrombotic effect of clopidogrel by almost half when taken concomitantly.

Administration with higher doses of PPIs, 2 hours after a PPI, or in combination with food and PPIs may reduce ledipasvir bioavailability.Lesinurad: Aspirin may diminish the therapeutic effect of Lesinurad. Management: Consider discontinuing drugs that may affect gallbladder motility prior to the use of sincalide to stimulate gallbladder contraction.SORAfenib: Proton Pump Inhibitors may decrease the absorption of SORAfenib.

If combined, increased monitoring for bleeding is recommended.Enoxaparin: Agents with Antiplatelet Properties may enhance the anticoagulant effect of Enoxaparin. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects may occur that usually do not need medical attention. Management: Coadministration of selpercatinib and proton pump inhibitors should be avoided.

Management: Carefully consider the anticipated risks and benefits of this combination. BackgroundWe evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. Proton Pump Inhibitors may decrease the serum concentration of Itraconazole. Management: Avoid this combination when possible since separation of doses is not likely to be an adequate method of minimizing the interaction.Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective): Aspirin may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective).

Apixaban: Aspirin may enhance the adverse/toxic effect of Apixaban.

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