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170, No. From the Department of Psychiatry, Division of Geriatric Psychiatry, USC School of Medicine; New York University School of Medicine, New York; and Pfizer Inc, New York. The protocol permitted use of chloral hydrate or temazepam on a limited, as-needed basis, and there were no significant between-group differences in the use of these hypnotics (16.2% [N=17] of the sertraline-treated and 13.3% [N=14] of nortriptyline-treated patients required hypnotics during the course of the study).The mean daily dose of nortriptyline from study week 4 on was 70 mg or above. Sign in via OpenAthens 22, No.

All analyses were performed for patients available at each study visit and at the last observation carried forward for each patient.A “mixed-model” ANOVA was employed for the analyses of change at multiple time points. DSM-5® Handbook on the Cultural Formulation InterviewThe Journal of Neuropsychiatry and Clinical Neurosciences Heart disease: Nortriptyline can cause slowed heart rate, resulting in heart attack, irregular heart rhythm and strokes. The lack of cardio-acceleratory effects also distinguished sertraline treatment from treatment with nortriptyline. 20, No. Concomitant sleep medications (permitted in the protocol) were used at a similar rate by patients taking both study drugs, providing an indirect confirmation of similar levels of sleep improvement.After 12 weeks of treatment with either sertraline or nortriptyline, perceived ability to function and quality of life, known to deteriorate in depressed older adults A methodological weakness of the current study is the lack of a placebo control. 2The American Journal of Geriatric Psychiatry, Vol. An ANCOVA model that used baseline as a covariate and that included treatment, center, and the center-by-treatment interaction found significantly greater improvement on the POMS total score and several of the POMS factor scores that began at week 2 for the patients treated with sertraline. To assess treatment-related changes in the associated symptoms of anxiety, the Hamilton anxiety scale total score, Hamilton depression scale anxiety/somatization factors, and the POMS anger/hostility and tension/anxiety factors were examined. GoodRx‘s cash prices are based on multiple sources, including published price lists, purchases, claims records, and data provided by pharmacies. The significance of mean changes from baseline were determined with respect to within-group and between-group differences by using least square means from two-way analysis of covariance (ANCOVA) models with baseline values as covariates.

7The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. Please read the entire Privacy Policy and Terms of Use. The benefits and risks of study participation were fully explained to each patient, and written informed consent was obtained.Following a 1-week, single-blind placebo washout period, patients were randomly assigned to 12 weeks of double-blind, parallel treatment with either sertraline (in a flexible daily dose of 50–150 mg) or nortriptyline (in a flexible daily dose of 25–100 mg) provided on a three times per day schedule. All significance levels were two-tailed and set at the 0.05 level.To compare sertraline- and nortriptyline-treated patients with respect to the time to achieve “responder” status and the time to achieve “remitter” status, a survival analysis that used Kaplan-Meier estimates of the survival function was used Primary outcome measures consisted of the change from baseline in Hamilton depression scale total score; responder status, defined a priori as a 50% or greater reduction from baseline in Hamilton scale score; and CGI severity and improvement scores.

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