It is not really recommended to use this medicine by pregnant women, only when there is … There is no general agreement about specific pharmacological treatment regimens for NMS.If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. Seroquel potentiated the cognitive and motor effects of alcohol in a clinical trial in subjects with selected psychotic disorders, and alcoholic beverages should be limited while taking quetiapine.Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) Tagamet HB is usually taken with meals or at bedtime. Patients with a pre-existing low WBC or a history of drug induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and should discontinue Seroquel at the first sign of a decline in WBC in absence of other causative factors.Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. Rare cases of NMS have been reported with Seroquel.

Seroquel should be used with caution in patients receiving medications having anticholinergic (antimuscarinic) effects [see Overdosage (10.1) and Clinical Pharmacology (12.1)]. Anaphylactic reactions have been reported in patients treated with Seroquel.Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. 7 Schizophrenia SEROQUEL is indicated for the treatment of schizophrenia. Common interactions include osteoporosis among females and diabetes mellitus among males. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile. Increasingly, atypical antipsychotic drugs are prescribed for elderly patients with symptoms of psychosis and behavioral disturbances. The Ki values for quetiapine and norquetiapine at the dopamine DQuetiapine and norquetiapine lack appreciable affinity to the benzodiazepine receptors.In clinical trials, quetiapine was not associated with a persistent increase in QT intervals. There are risks to the mother associated with untreated schizophrenia, bipolar I, or major depressive disorder, and with exposure to antipsychotics, including Seroquel, during pregnancy (see Clinical Considerations).In animal studies, embryo-fetal toxicity occurred including delays in skeletal ossification at approximately 1 and 2 times the maximum recommended human dose (MRHD) of 800 mg/day in both rats and rabbits, and an increased incidence of carpal/tarsal flexure (minor soft tissue anomaly) in rabbit fetuses at approximately 2 times the MRHD.
The reduction in total and free thyroxine (TIn the mania adjunct studies, where Seroquel was added to lithium or divalproex, 12% (24/196) of Seroquel treated patients compared to 7% (15/203) of placebo-treated patients had elevated TSH levels. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.The management of NMS should include: 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy; 2) intensive symptomatic treatment and medical monitoring; and 3) treatment of any concomitant serious medical problems for which specific treatments are available. The risk of orthostatic hypotension and syncope may be minimized by limiting the initial dose to 25 mg twice daily Atypical antipsychotic drugs, including Seroquel, may cause somnolence, postural hypotension, motor, and sensory instability, which may lead to falls and, consequently, fractures or other injuries.
Patients randomized to Seroquel were administered fixed doses of either 300 mg or 600 mg once daily.The primary rating instrument used to assess depressive symptoms in these studies was the Montgomery-Asberg Depression Rating Scale (MADRS), a 10-item clinician-rated scale with scores ranging from 0 to 60.

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