Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020

S, Glynn. Evaluation of 2 tuberculosis chemoprophylaxis regimens in patients infected with human immunodeficiency virus.

Not infected with mycobacteria tuberculosis, with a negative reaction to tuberculin, - When choosing drugs for chemoprophylaxis, particular importance is attached to the efficacy and specificity of their action on the mycobacterium tuberculosis, the most justified consider the use of preparations of hydrazide isonicotinic acid and its analogues. x��UKo1��W�F�0i켏�[JQ�t;-B�B��� ';�vw��H+;q�ϟ�I (M��~%��Q>�uY.�z��Q.߯�qG�����A�svf��:��M�d�J6�O�b�&y2� %PDF-1.4

The epidemiology of drug-induced systemic lupus erythematosus. Apply isoniazid at a dose of 10 mg / kg for 3 months after the detection of a positive or hyperergic reaction to tuberculin, while maintaining a positive reaction appoint a second course of chemotherapy for 3 months with two drugs.Taking drugs from the group of isonicotinic acid hydrazides and their analogs allows to obtain a satisfactory protective effect, but their hepatotoxicity and the likelihood of development of drug resistance in mycobacteria of tuberculosis with long-term isoniazid intake (6-12 months) determine the urgency of finding other possibilities.The growth of drug resistance in mycobacteria of tuberculosis and the decrease in the effectiveness of treatment of tuberculosis patients are largely due to irregular intake of drugs or failure to adhere to the optimal treatment regimen (doses and multiplicity of admission). endobj More effective treatment of LTBI will facilitate TB elimination (Although 9 months of isoniazid was a preferred regimen in the guidelines published in 2000, both 6 and 9 months of isoniazid were recommended at that time (Two months of rifampin plus pyrazinamide are not recommended for treatment of LTBI because of the hepatotoxicity risk. For adults and adolescents, the daily dose of isoniazid for daily intake is 0.3 g, for children 8-10 mg / kg. Second, the committee did not evaluate evidence regarding how to implement these regimens programmatically (e.g., who to test and treat and management of side effects). Strong GRADE recommendations required at least moderate evidence of effectiveness and that the desirable consequences outweighed the undesirable consequences in the majority of patients. Sensitivity to tuberculin in the Mantoux reaction with 2 TE PPD-L expressed, hyperergic, sensitivity threshold - by the 6th dilution and more, positive reactions - by 3 dilutions and more graded reaction Pirke. 1992;(196-197):69-71. Apply isoniazid at a dose of 10 mg / kg for 3 months after the detection of a positive or hyperergic reaction to tuberculin, while maintaining a positive reaction appoint a second course of chemotherapy for 3 months with two drugs. This regimen, administered through directly observed therapy, had equivalent effectiveness and was not more toxic than the standard regimen of 9 months of daily isoniazid in adults and children aged >2 years (Potential disadvantages of this regimen include cost of medications that are greater than most alternatives, potential added costs if provided by directly observed therapy (with treatment completion being highest with directly observed therapy, although self-administered therapy is an approved option) (A regimen of 4 months of daily rifampin is a preferred treatment that is strongly recommended for HIV-negative adults and children of all ages. The committee had expertise in epidemiology, domestic and international TB control, clinical trials, and treatment of LTBI in adults and children.

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