All of these reactions are generally transient in nature and usually do not require treatment. DOSAGE AND ADMINISTRATION. This response is part of the fight-or-flight response. It is soluble in water and in 0.1N hydrochloric acid, slightly soluble in methanol, and insoluble in chloroform. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Adverse reactions observed with terbutaline are similar to those commonly seen with other sympathomimetic agents. Serious adverse reactions, including death, have been reported after administration of terbutaline sulfate to pregnant women. Oral terbutaline should no longer be taken. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.
Do not use if solution is discolored.A sterile aqueous solution for subcutaneous injection.Terbutaline sulfate has not been approved and should not be used for prolonged tocolysis (beyond 48 to 72 hours).
The clinical significance of these findings is unknown.
Each milliliter of solution contains 1 mg of Terbutaline sulfate USP (0.82 mg of the free base), sodium chloride for isotonicity, and hydrochloric acid for adjustment to a target pH of 4.
For Child 2–14 years. A few women have more serious side effects, such as irregular heartbeats, extra …
Terbutaline Side effects. While most pregnant women go into labor at the 40-week mark, some women go into labor earlier.
In the same study, after 3 days only 30% to 50% of the dose was recovered from urine and the remainder from the feces, which may indicate poor absorption.After an oral dose to asthmatic patients, the elimination half-life of terbutaline was approximately 3.4 hours.In comparison to oral dosing, subcutaneous administration of 0.5 mg of terbutaline sulfate to 17 healthy, adult, male subjects resulted in a mean (SD) peak plasma terbutaline concentration of 9.6 (3.6) ng/mL, which was observed at a median (range) time of 0.5 (0.08 to 1.0) hours after dosing. Serious adverse reactions, including death, have been reported after administration of terbutaline sulfate to pregnant women. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm.
In the mother, these adverse reactions include increased heart rate, transient hyperglycemia, hypokalemia, cardiac arrhythmias, pulmonary edema and myocardial ischemia. Terbutaline Interactions. Asthma, Bronchodilation in COPD and Toxic inhalation. If the patient needs more doses of terbutaline sulfate than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and the treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids.The use of beta-adrenergic agonist bronchodilators alone may not be adequate to control asthma in many patients.
Terbutaline sulfate should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. The pharmacologic effects of beta-adrenergic agonists, including terbutaline, are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic 3’,5’-adenosine monophosphate (cAMP). DESCRIPTION.
Terbutaline is classified as a pregnancy risk category C drug. The total dose of terbutaline shouldn’t exceed 0.5 mg, and the medication shouldn’t be used for more than two days at a time.
After subcutaneous administration of 0.25 mg of terbutaline to two male subjects, peak terbutaline serum concentrations of 5.2 and 5.3 ng/mL were observed at about 20 minutes after dosing.Elimination half-life of the drug in 10 of 14 patients was approximately 2.9 hours after subcutaneous administration, but longer elimination half-lives (between 6 to 14 hours) were found in the other 4 patients. The total dose within 4 hours should not exceed 0.5 mg.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Protect from light. Women respond differently to terbutaline, so its effects and how long they last vary from one woman to another.
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