Low-dose theophylline would reduce the risk of adverse effects and has the potential to bring theophylline back into more mainstream use.At the American Thoracic Society meeting in San Diego in May, David Price presented the At the end of Price's presentation, a member of the audience posed the question: is this the death of low-dose theophylline for COPD?
Accessed 5/14/2018.
Theophylline is thought to potentially increase the sensitivity of inhaled corticosteroids in people with COPD by increasing the activity of HDAC2, which regulates the acetylation of core histones associated with the pro-inflammatory genes that drive chronic airway inflammation.
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The role of theophylline in the treatment of asthma and the management of acute exacerbations of COPD and of stable COPD are discussed separately. These features are most prominent in patients with moderate to severe COPD, but even patients with mild COPD can experience exacerbations.1 Acute exacerbation of COPD (AECOPD) is characterized by an increase in dyspnea, cough and/or sputum that is beyond normal day-to-day variation. COPD Treatment. EFFECTS ON FUNCTIONAL IMPAIRMENT
We use cookies to help provide and enhance our service and tailor content and ads. The reliability of using this history to guide aminophylline therapy is, however, unclear. 1 This recommendation follows … Price noted that, in people with COPD at high risk of exacerbation, no benefit comes from the addition of low-dose theophylline, but a study in patients with frequent exacerbations who are being admitted to hospital might be warranted.
Related agents caffeine and theobromine were used in the 1930s as bronchodilators, and theophylline developed an established place in the management of acute airflow obstruction associated with asthma and chronic obstructive pulmonary disease (COPD) during the mid 1900s.
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This seems unlikely given the number of participants required for an adequately powered study in this select subgroup. Theophylline agents used for COPD are maintenance or long-term control drugs. The guidelines of the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease (GOLD) currently recommend consideration of the addition of an oral or intravenous methylxanthine to aerosolised bronchodilators for severe exacerbations of chronic obstructive pulmonary disease (COPD). By continuing you agree to the It has two different mechanisms of actionin people with reversible lung obstruction: as a bronchodilator, it causes smooth muscle relaxation.
Patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) frequently report a history of theophylline use prior to arrival in the emergency department. Theophylline is part of the methylxanthines class.
We do not endorse non-Cleveland Clinic products or services. Theophylline products are Elixophyllin®, Theobid®, Theo-24®, T-phyl®, and Uniphyl®.
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