Propranolol (Inderal, Inderal LA, Inderal XL, InnoPran) Timolol ; As many as 4 out of 5 of people who take beta-blockers get relief from their migraines. In blacks, verapamil lowered systolic BP 16.9 vs 8.1 mm Hg for propranolol; verapamil reduced diastolic BP 12.8 vs 8.6 mm Hg for propranolol. Both drugs were equally well tolerated and caused no patient withdrawals. Changes in blood biochemistry values were of small magnitude. sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto download free article PDFs, sign up for alerts, customize your interests, and moreto make a comment, download free article PDFs, sign up for alerts and more By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. However, according to the National Headache Foundation, "recent genetic studies have suggested that calcium channels in nerve cells may not function normally in migraine. Recent reports have confirmed that slow calcium channel inhibitors have useful antihypertensive properties because they produce dilatation of the peripheral arterioles without reflex tachycardia. Their clinical place in the management of hypertension has yet to be clearly defined, and thus we have performed an open crossover trial to compare the 24-hour profiles of blood pressure reduction after chronic therapy with propranolol and verapamil. Nineteen patients were studied by continuous ambulatory intraarterial recording and the order of drug administration was decided by random allocation. sign up for alerts, and moreto download free article PDFs, 3 patients withdrew, but none because of side-effects. Like all calcium channel blockers, verapamil prevents calcium from entering smooth muscle cells, which allows them to relax and prevents constriction of blood vessels. All Rights Reserved 1986;256(16):2214-2221. doi:10.1001/jama.1986.03380160072023© 2020 American Medical Association. The PR interval was increased from 163.5 to 174.9 ms for verapamil vs 160.3 to 164.4 ms for propranolol. "2 In other …

Heart rate was reduced by 6.0 beats per minute by verapamil, and by … This is why these medications are theorized to help prevent migraines. A Comparison of Verapamil and Propranolol for the Initial Treatment of HypertensionCustomize your JAMA Network experience by selecting one or more topics from the list below.From the Division of Clinical Pharmacology, University of North Carolina, Chapel Hill (Dr Cubeddu); the Cardiology Service, Veterans Administration Hospital, San Juan, Puerto Rico (Dr Aranda); the Division of Cardiology, Wadsworth Veterans Administration Hospital, San Francisco (Dr Singh); Coronary Care, Boston University Medical Center, Boston (Dr Klein); Brachfeld Medical Associates, Zurgrugg Memorial Hospital, Willingboro, NJ (Dr Brachfeld); the Veterans Administration Hospital, Washington, DC (Dr Freis); the Renal Unit, Veterans Administration Medical Center, Salem, Va (Dr Roman); and Cardiovascular Associates, San Antonio, Tex (Dr Eades). We compared verapamil and propranolol hydrochloride for monotherapy of hypertension. and propranolol in 40 mg b.i.d. Increases in systolic BP were observed in 22% and 3.4% of patients receiving propranolol and verapamil, respectively. Verapamil lowered blood pressure (BP) more effectively than propranolol in black and white patients. We conclude that verapamil monotherapy is a safe and effective means of achieving BP control in patients with essential hypertension.Cubeddu LX, Aranda J, Singh B, et al. Heart rate was reduced by 6.0 beats per minute by verapamil, and by 13.6 beats per minute by propranolol. This slow calcium channel inhibitor may be useful as initial therapy for hypertension, particularly for those patients in whom beta-adrenoreceptor blockers are contraindicated.We use cookies to help provide and enhance our service and tailor content and ads. Constipation (15%) and headaches (10%) were most frequent complaints for verapamil vs fatigue (18%) and dizziness (7%) for propranolol. Verapamil was equally effective in blacks and whites, whereas propranolol was more effective in whites.

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