It is specifically used to treat multi-drug-resistant tuberculosis (MDR-TB) when other treatment cannot be used. Usage on vi.wikipedia.org Bedaquiline; Usage on www.wikidata.org Q1257318; Metadata. Bedaquiline, sold under the brand name Sirturo, is a medication used to treat active tuberculosis. Label expansion marks important milestone in Johnson & Johnson’s pediatric research and development program for bedaquiline .

I have already seen media reports from India which call bedaquiline a ‘miracle drug’. This page was last edited on 14 June 2018, at 14:00. Bedaquiline is a promising new TB drug but it must be carefully introduced and monitored. You could also do it yourself at any point in time.It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those … Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Most infections show no symptoms, in which case it is known as latent tuberculosis. [20] Bedaquiline is bactericidal. Every page goes through Brc1ccc2nc(OC)c(cc2c1)[C@@H](c3ccccc3)[C@](O)(c5c4ccccc4ccc5)CCN(C)CInChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1✪ Unacademy Science and Technology for UPSC: Bedaquiline : Definition, Facts & Significance​✪ Hope in the Pipeline: New Drugs (Bedaquiline/Sirturo, Delamanid/Deltyba)✪ Organic Chemistry 51B. [21] It has a role as an antitubercular agent and an ATP synthase inhibitor. Mutations in atpE can lead to resistance. Would you like Wikipedia to always look as professional and up-to-date? [20] ATP production is required for cellular energy production and its loss leads inhibition of mycobacterial growth within hours of the addition of bedaquiline. [20] It is the first member of a new class of drugs called the diarylquinolines. Bedaquiline was approved for medical use in the United States in 2012.It is a component of the experimental BPaMZ combination treatment (bedaquiline + The most common side effects of bedaquiline in studies were nausea, joint and chest pain, and headache. It should be used along with at least three other medications for tuberculosis. Bedaquiline fumarate is a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid.It is used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. Mutations in drug Bedaquiline was described for the first time in 2004 at the Interscience Conference on Antimicrobial Agents and Chemotherapy (Bedaquiline was approved for medical use in the United States in 2012.When it was approved by the FDA on 28 December 2012, it was the first new medicine for TB in more than forty years.In 2016, the WHO came under criticism for recommending it as an essential medicine.Congratulations on this excellent venture… what a great idea!I use WIKI 2 every day and almost forgot how the original Wikipedia looks like. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. We have created a browser extension. The drug also has a There is considerable controversy over the approval for the drug, as one of the largest studies to date had more deaths in the group receiving bedaquiline that those receiving placebo.Bedaquiline should not be co-administered with other drugs that are strong inducers or inhibitors of Since bedaquiline can also prolong the QT interval, use of other QT prolonging drugs should be avoided.The specific part of ATP synthase affected by bedaquiline is subunit c which is encoded by the gene atpE.

Bedaquiline Fumarate.

Mutations in atpE can lead to resistance. This worries me – terms like ‘miracle drug’ should not be used lightly as it can raise expectations and also encourage abuse. Mutations in drug Bedaquiline was described for the first time in 2004 at the Interscience Conference on Antimicrobial Agents and Chemotherapy (Bedaquiline was approved for medical use in the United States in 2012.When it was approved by the FDA on 28 December 2012, it was the first new medicine for TB in more than forty years.In 2016, the WHO came under criticism for recommending it as an essential medicine.Brc1ccc2nc(OC)c(cc2c1)[C@@H](c3ccccc3)[C@](O)(c5c4ccccc4ccc5)CCN(C)CInChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1

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