lower respiratory tract infections in which a higher dose of ZOSYN was used in informational and educational purposes only. 2002 Tell your doctor right away if you develop rash, peeling, sores or blisters on the skin. varying conditions, adverse reaction rates observed in the clinical trials of a Your list will be saved and can be edited at any time.The above information is provided for general Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool. Serious skin reactions can occur. and formulary information changes. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. In addition to the adverse drug reactions identified in Controlled studies in pregnant women show no evidence of fetal risk.Antipseudomonal penicillin plus beta-lactamase inhibitor; inhibits biosynthesis of cell wall mucopeptide synthesis by binding to 1 or more of the penicillin-binding proteins and is effective during active-multiplication stageLungs, intestinal mucosa, skin, muscle, uterus, ovary, prostate, gallbladder, and bile; low CSF penetration in noninflamed meningesHepatic to desethyl metabolite (piperacillin) and inactive metabolite (tazobactam)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Call your doctor for medical advice about side effects. Peak serum concentrations of piperacillin and tazobactam are attained immediately after the completion of the infusion. Indicated for treatment of appendicitis (complicated by rupture or abscess) and peritonitis caused by beta-lactamase producing isolates of Escherichia coli or the following members of the Bacteroides fragilis group: B fragilis, B ovatus, B thetaiotaomicron, or B vulgatus3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 daysIndicated for treatment of nosocomial pneumonia (moderate to severe) caused by beta-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosaNosocomial pneumonia caused by P aeruginosa should be treated in combination with an aminoglycoside4.5 g IV q6hr (totaling 18 g [16 g piperacillin/2 g tazobactam]) for 7-14 days; continue aminoglycoside in P. aeruginosa patientsIndicated for treatment of uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections caused by beta-lactamase producing isolates of3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 daysIndicated in treatment of postpartum endometritis or pelvic inflammatory disease caused by beta-lactamase producing isolates of3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 daysIndicated for the treatment of community-acquired pneumonia (moderate severity only) caused by beta-lactamase producing isolates of 3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 daysTo reduce the development of drug-resistant bacteria and maintain the effectiveness of antibacterial drugs, use only to treat or prevent infections that are proven or strongly suspected to be caused by bacteriaWhen culture and susceptibility information are available, consider selecting or modifying antibacterial therapyIn the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapyIndicated for treatment of appendicitis (complicated by rupture or abscess) and/or peritonitis in adult and pediatric patients aged ≥2 months caused by beta-lactamase producing isolates of Escherichia coli or the following members of the Bacteroides fragilis group: B fragilis, B ovatus, B thetaiotaomicron, or B vulgatusIndicated for treatment of nosocomial pneumonia (moderate to severe) in adult and pediatric patients aged ≥2 months caused by beta-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosaNosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycosideTo reduce the development of drug-resistant bacteria and maintain the effectiveness of antibacterial drugs, use only to treat or prevent infections that are proven or strongly suspected to be caused by bacteriaWhen culture and susceptibility information are available, consider selecting or modifying antibacterial therapyIn the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapyHematologic: Hemolytic anemia, agranulocytosis, pancytopeniaImmune: Hypersensitivity reactions, anaphylactic/anaphylactoid reactions (including shock)Skin and appendages: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, dermatitis exfoliativeRespiratory, thoracic and mediastinal disorders: Epistaxis, eosinophilic pneumoniaDrug reaction with eosinophilia and systemic symptoms (DRESS)Allergy to penicillins, cephalosporins, imipenem, beta-lactamase inhibitorsRisk of bleeding complications, especially in renal impairment; discontinue if thrombocytopenia or bleeding occursLeukopenia/neutropenia associated with prolonged therapy; periodic assessment of hematopoietic function should be performed, especially with prolonged therapy that is ≥ 21 daysSerious skin reactions reported, including Stevens-Johnson syndrome and toxic epidermal necrolysis, generalized exanthematous pustulosis; discontinue if reaction occursMonitor renal, hepatic, and especially hematopoietic functions during prolonged treatmentProlonged use may result in fungal or bacterial superinfectionAdministering therapy in absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteriaClostridium difficile associated diarrhea (CDAD) reported; if CDAD suspected or confirmed, may need to discontinue ongoing antibacterial drug use not directed against C. difficile; appropriate fluid and electrolyte management, protein supplementation may need to be implemented; antibacterial treatment of C. difficile, and surgical evaluation should be instituted as clinically indicatedIncreased frequency of rash and fever reported in cyctic fibrosis patients receiving piperacillinRisk of seizures may increase in patients with history of seizures when administered at higher than recommended doses given IV in the presence of renal impairmentConsider sodium content (2.79 mEq/g piperacillin) in patients requiring sodium restrictionPerform periodic electrolyte determinations in patients with low potassium reserves and who are receiving cytotoxic therapy or diuretics and consider possibility of hypokalemia in patients who have potentially low potassium reservesIncreased frequency of fever and rash reported in patients with cystic fibrosis receiving piperacillinUse caution in patients with renal impairment or underdeveloped kidneys due to sodium load and adverse effects of high serum concentrations of penicillin; dose adjustment may be necessaryPatients may experience neuromuscular excitability or convulsions if higher than recommended doses are given IV (particularly in presence of renal failure); closely monitor patients with renal impairment or seizure disorders for signs and symptoms of neuromuscular excitability or convulsions (seizures)Piperacillin and tazobactam cross placenta in humansInsufficient data available with piperacillin and/or tazobactam in pregnant women to inform a drug-associated risk for major birth defects and miscarriagePiperacillin is excreted in human milk; tazobactam concentrations in human milk have not been studiedNo information available on effects of piperacillin and tazobactam on breastfed child or on milk productionA: Generally acceptable.

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