The objective of this paper was to review and evaluate the literature on metronidazole-associated peripheral neuropathy and determine the relevance in clinical practice. It was interesting to observe that the results varied according to the length of antibiotic treatment and our findings suggest that risk may not be the same for everyone.
Metronidazole is a nitroimidazole antibiotic that was introduced in the 1950s. A person prescribed with amoxicillin-clavulanate were not significantly more likely to experience peripheral neuropathy.The risk was higher for men and rose with age and with the length of fluoroquinolone treatment. In addition, we reviewed 13 clinical studies and found varying rates of peripheral neuropathy from 0 to 50%. This antibiotic has been associated with peripheral neuropathy. Symptoms include pain, burning, tingling, numbness, weakness, or a change in sensation to light touch, pain or temperature, or the sense of body position. 2020 Jan 8;7(1):4. doi: 10.3390/medicines7010004.Curr Infect Dis Rep. 2019 Aug 31;21(10):34. doi: 10.1007/s11908-019-0688-3.Toxicol Pathol. 2020;10(2):225-244. doi: 10.1016/j.jcmgh.2020.04.003. Medications causing the neuropathy may be stopped or altered Over-the-counter pain medication for mild pain. Antibiotic-induced neuropathy is a rare complication of several antimicrobial agents. Our review found 36 case reports (40 unique patients) of metronidazole-associated peripheral neuropathy, with most cases (31/40) receiving a >42 g total (>4 weeks) of therapy.
by Grant Hill, Research from the University of Dundee has shown that a commonly used class of antibiotics may increase a patient's risk of suffering a serious and potentially permanent form of nerve damage by almost 50 percent. However, further studies confirming or refuting this risk were limited, in particular those aimed at quantifying risk and examining how it may vary among different people.Dr. Flagyl (metronidazole)." Applies to metronidazole: oral capsule, oral powder for suspension, oral tabletOther dosage forms: 1. intravenous solutionAlong with its needed effects, metronidazole (the active ingredient contained in Flagyl) may cause some unwanted effects. Overview.
Epub 2019 Jul 22. MEDLINE/PubMed, EBSCO, and Google Scholar were searched through February 2017 using the search terms metronidazole … classes of antibiotics as they have been described in the medical literature over the last several decades,the poten-tial mechanisms and management strategies. In this article, the author discusses antibiotics that have been associated with peripheral neuropathy, focusing on those in general use and with the most established associations, and detailing the possible underlying pathophysiologic mechanisms leading to neuropathy.
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"Fluoroquinolones are effective antibiotics but health care professionals should recognise that peripheral neuropathy may rarely occur following fluoroquinolone therapy.
Searle, Skokie, IL. By using our site, you acknowledge that you have read and understand our O 0Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. We do not guarantee individual replies due to extremely high volume of correspondence. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking metronidazole: Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox
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