In addition the BKV peak viral loads in blood reaching 223 000 copies/ml at any time was found to be predictive for BKVAN (91% specificity and 88% sensitivity) .This virus can be diagnosed by a BKV blood test or a urine test for The cornerstone of therapy is reduction in immunosuppression. The BK virus rarely causes disease but is typically associated with patients who have had a kidney transplant; many people who are infected with this virus are The virus then disseminates to the kidneys and urinary tract where it persists for the life of the individual. Once you get a BK virus infection, the virus stays in your system for good. Listing a study does not mean … This is called latent, or like being ‘asleep’ in your body. The BK virus is a member of the polyomavirus family. Primary BK virus infection is proposed as the cause of a variety of renal diseases, including hemorrhagic and nonhemorrhagic cystitis in immunocompetent and immunocompromised patients . COVID-19 is an emerging, rapidly evolving situation. BKV accompanies by JC (John Cunningham) virus and Simian virus 40 belongs to polyomaviridae family. Typically, this is in the setting of It is not known how this virus is transmitted. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.This is a pilot study using cytotoxic T lymphocytes (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Gamma-capture system will be effective in decreasing specific viral load in patients with BK virus viremia and BK virus-associated symptoms post-allogeneic hematopoietic stem cell transplantation (HSCT), renal transplantation, and chemotherapy.This open-label, single-arm clinical trial will assess the safety and efficacy of BK virus-specific CTLs isolated from whole blood or leukapheresis products. The BK virus -specific CTLs will be generated automatically by the CliniMACS® Prodigy using the CliniMACS Cytokine Capture System (IFNgamma) after incubation with MACS GMP PepTivator® Peptide Pools of BKV VP1 and BKV LT.All patients with symptoms that are consistent with BK cystitis and/or nephropathy (frequency, dysuria, hematuria, elevated creatinine) will have serum quantitative DNA PCR for BK virus level measured in log copies per mL (results also expressed in copies per milliliter), performed in the Children's Hospital of Philadelphia Infectious Disease Diagnostics LaboratoryNumber of participants with Grade III-IV acute GVHD as assessed by CTCAE v4.0Number of patients with undetectable BK viral load as measured by qPCR

Past infection with the BK virus is widespread, but significant consequences of infection are uncommon, with the exception of the immunocompromised and the immunosuppressed.BK virus is an abbreviation of the name of the first patient whom the virus was isolated from in 1971 (the patient was then 29 years old).

HLA Matched Related Donors: BK-virus specific CTLs (2.5 x 104 CD3/kg) infused intravenously on day 0 and may be additionally reinfused at a minimum of every two weeks (depending on safety and efficacy) for a maximum of five total infusions (maximum 12.5 x 104 CD3/kg).HLA Mismatched Related Donors: BK-virus specific CTLs (0.5x104 CD3/kg) infused intravenously on day 0 and may additionally be reinfused at a minimum of every two weeks (depending on safety and efficacy) for a maximum of five total infusions (maximum 2.5 x 104 CD3/kg).Patients with symptoms of cystitis and elevated BK virus DNA by screening PCR as above (section 4) post allogeneic HSCT, post chemotherapyRelated donor available with a T-cell response to the BK-virus MACS® PepTivator® antigen(s).Third Party Allogeneic Donor: If original donor is not available or does not have a T-cell response: third party allogeneic donor (family donor > 1 HLA A, B, DR match to recipient) with a T-cell response to the BK MACS® PepTivator.• Obtained informed consents by donor or donor legally authorized representative prior to donor collection.A patient meeting any of the following criteria is not eligible for the present study:

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