JAC vol.54 no.6 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved Based on this and other similar studies,Comparisons of patients with reported penicillin allergy and without penicillin allergyComparisons of patients with reported penicillin allergy and without penicillin allergy1Infectious Diseases, Huron Hospital — Cleveland Clinic Health System, East Cleveland, OH; 2Pharmacy, Hillcrest Hospital — Cleveland Clinic Health System, Mayfield Heights, OH, USAOxford University Press is a department of the University of Oxford.

For more information view the When carbapenems were first introduced, it was recommended to use them cautiously in patients with a penicillin allergy due to an approximately 50% potential risk of cross-sensitivity in these patients. Allergy information was obtained from a patient interview by a pharmacist or from the electronic medical record. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent.Create a link to share a read only version of this article with your colleagues and friends.

Interestingly, only one out of the 10 patients who reported anaphylaxis with penicillin administration developed a reaction to the carbapenem. Find out about Lean Library If you have access to journal via a society or associations, read the instructions belowAccess to society journal content varies across our titles.If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box.Contact us if you experience any difficulty logging in.Some society journals require you to create a personal profile, then activate your society accountYou are adding the following journals to your email alertsDid you struggle to get access to this article? Seven (12.3%) out of 57 patients who reported rash as a reaction to penicillin also developed a reaction to the carbapenem. This tendency was most notable in patients with both penicillin and cephalosporin allergies. By continuing to browse These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens.

Allergy to imipenem/cilastatin and meropenem was based on the appearance of a hypersensitivity reaction, which resolved upon discontinuation of the carbapenem.

Sixty of the patients identified without penicillin allergies were not included due to the unavailability of the charts or not meeting inclusion criteria. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Eravacycline, a novel tetracycline derivative, does not induce This site uses cookies. Find out about Lean Library Research off-campus without worrying about access issues.

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New login is not successful because the max limit of logins for this user account has been reached.Login failed. It may be prudent to use caution when prescribing carbapenems in patients with multiple antibiotic allergies. Fifty-seven percent (4/7) of the patients with both allergies also had an allergic reaction to the carbapenem. Eleven observational studies on carbapenem cross-reactivity involving 1127 penicillin-allergic patients showed that the risk of cross-reactivity to any carbapenem was 0.87% (95% CI, 0.32-2.32).

There have been reports of individuals with a history of penicillin hypersensitivity that have experienced severe hypersensitivity reactions when treated with another beta-lactam. Find out about Lean Library If you have an individual subscription to this content, or if you have purchased this content through Simply select your manager software from the list below and click on download. This patient developed a maculopapular rash as a reaction to the carbapenem.Patients with a history of penicillin allergy had a 9.2% incidence of a carbapenem allergic reaction compared with 3.9% of the patients with no penicillin allergy. BACKGROUND: Cross-reactivity between penicillins or cephalosporins and carbapenems is anticipated as all have a beta lactam ring.

Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins.

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