Cross, Michael J. Berman I, Zalma A, Durand CJ, Green AI: Clozapine-induced myoclonic jerks and drop attack [Letter]. Feltus MS, Gardner DM: Second generation antipsychotics for schizophrenia. Safferman AZ, Lieberman AJ, Kane JM: Syzmanski S, Kinon B: Update on the clinical efficacy and side effects of clozapine. Karagianis JL, Phillips LC, Hogan KP, LeDrew KK: Clozapine-associated neuroleptic malignant syndrome: Two new cases and a review of the literature. Pope HG Jr, Cole JO, Choras PT Fulwiler CE: Apparent neuroleptic malignant syndrome with clozapine and lithium.

Spina, Edoardo Development of the Clozaril Patinet Management System [Abstract]. Clozapine is an atypical antipsychotic that is used for treatment-resistant schizophrenia.

* Views captured on Cambridge Core between . Frankenburg FR, Kando J: Eosinophilia, clozapine and pancreatitis [Letter]. Smoking and clozapine To have equivalent blood levels, non-smokers need lower doses of clozapine than smokers (perhaps up to 50% lower) (1, 3).

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Corrigan FM, MacDonald S, Reynolds GP: Clozapine-induced hypersalivation and the alphaAronowitz JS, Safferman AZ, Lieberman JA: Management of clozapine induced enuresis [Letter]. Testani M: Clozapine-induced orthostatic hypotension treated with fludrocortisone. Lieberman JA, Yunis J, Egen E, Canoso RT, Kane JM, Yunis EJ: HLA-B38, DR4, DQw3 and clozapine induced agranulocytosis. Gouzoulis E, Ozdaglar A, Kasper J: Myoclonic seizures followed by grand mal seizures during clozapine treatment [Letter].

Other side effects include: syncope, and diaphoresis.

Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Litran RE, Hong WW, Weissman EM, Su TP, Potter WZ, Pickar D: Idazoxan, an alphaBrown CS, Markowitz JS, Moore TR, Parker NG: Atypical antipsychotics: Part II–Adverse effects, drug interactions and costs. Guise-Honore, S. Bastani B, Alphs LD, Meltzer HY. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of clozapine may occur that usually Check with your health care professional if any of the following side effects The most commonly reported side effects included salivary hypersecretion, somnolence, and weight gain.The cumulative incidence of seizure at 1 year is approximately 5% based on pre-marketing testing. Breefa D, Meehan T: Weight changes during clozapine treatment. Bambina, E. Macfarlane B, Davies S, Mannan K, Sarsam R, Pariente D, Dooley J: Fatal acute fulminant liver failure due to clozapine: A case report and review of clozapine-induced hepatotoxicity. 2018. Schuster P, Gabriel E, Kufferle B, Strobl G, Karobath M: Reversal by physostigmine of clozapine-induced delirium.

Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Some side effects may occur that usually do not need medical attention. Wirshing DA, Wirshing WC, Kysar L, Berisfor MA, Goldstein D, Pashdag J, Mintz J, Marder SR: Novel antipsychotics: Comparison of weight gain liabilities. Jazz Pharmaceuticals, Palo Alto, CA. Liukkonen J, Koponen HJ, Nousiainen U: Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment. Non-psychotropic medications associated with increase in clozapine levels include: erythromycin, ciprofloxacin, omeprazole, cimetidine, OCP containing ethinylestradiol, amiodarone, aluminum hydroxide and isoniazid. "Product Information. Oral route (Suspension; Tablet; Tablet, Disintegrating)Risks associated with the use of clozapine include severe Along with its needed effects, clozapine may cause some unwanted effects. Berlan M, Montastruc J-M, Lafontan M: Pharmacological prospects for alphaPearlmen C. Clozapine, nocturnal sialorrhea, and chocking [Letter]. Silver JM, Yudofsky SC, Jurowitz GI: Psychopharmacology and electroconvulsive therapy.

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