Haemodynamic evaluation of PH severity should be contextualised within the extent of the underlying lung disease, which is best gauged through a combination of physiological and imaging assessment. Therefore, these patients should be a target population for larger prospective studies. We present a two-part review of the English-language literature pertaining to drug therapy for systemic high BP in patients with pulmonary diseases. The potential role of systemic inflammation in chronic obstructive pulmonary diseaseA randomized, controlled trial of bosentan in severe COPDLong term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema: Report of the Medical Research Council working partyTargeting Nrf2 with the triterpenoid CDDO‐imidazolide attenuates cigarette smoke‐induced emphysema and cardiac dysfunction in miceReversal of elastase‐induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in miceMulti‐institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseasesPulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantationHemodynamic response to oxygen therapy in chronic obstructive pulmonary diseaseDiffusion capacity and BMPR2 mutations in pulmonary arterial hypertensionEffect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary diseaseMyeloperoxidase: Molecular mechanisms of action and their relevance to human health and diseaseGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summarySildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trialArterial vascular pruning, right ventricular size, and clinical outcomes in chronic obstructive pulmonary disease. There are two treatments available so far, which are not mutually exclusive: vasodilators and long-term oxygen therapy (LTOT). A longitudinal observational studyThe effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclaseStimulation of soluble guanylate cyclase prevents cigarette smoke‐induced pulmonary hypertension and emphysemaPulmonary hemodynamics in patients with chronic obstructive pulmonary disease before and during an episode of peripheral edemaLong‐term oxygen therapy can reverse the progression of pulmonary hypertension in patients with chronic obstructive pulmonary diseasePulmonary arterial enlargement and acute exacerbations of COPDA pathophysiological study of 10 cases of hypoxic cor pulmonaleSystemic inflammation in chronic obstructive pulmonary disease: The role of exacerbationsEffect of long‐term cigarette smoke exposure on pulmonary vascular structure and function in the guinea pigSmoking cessation decreases the number of metaplastic secretory cells in the small airways of the guinea pigAnimal models of chronic obstructive pulmonary diseaseAnalysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health nocturnal oxygen therapy trialStatin reverses smoke‐induced pulmonary hypertension and prevents emphysema but not airway remodelingCigarette smoke extracts promote vascular smooth muscle cell proliferation and enhances contractile responses in the vasculature and airwayPalifermin induces alveolar maintenance programs in emphysematous miceRtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke‐induced pulmonary injury and emphysemaEffect of chemokine receptor CXCR4 on hypoxia‐induced pulmonary hypertension and vascular remodeling in ratsEffect of statins on COPD: A meta‐analysis of randomized controlled trialsEffects of long‐term oxygen therapy on pulmonary hemodynamics in COPD patients: A 6‐year prospective studyInternational Journal of Chronic Obstructive Pulmonary Disease, International Journal of Chronic Obstructive Pulmonary Disease,

from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (PI17/1515), Fondo Europeo de Desarrollo Regional (FEDER, European Regional Development Fund) Unión Europea, “Una manera de hacer Europa,” Sociedad Española de Neumología y Cirugía Torácica (SEPAR), and SOCAP.

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