TD, Buchner  C, Honig The cognitive impact of anticholinergics: a clinical review. Please enable it to take advantage of the complete set of features! Larson JAMA Intern Med. Our secondary analyses revealed no significant interactions with sex, age at entry, or In this population-based, longitudinal study of persons 65 years or older, we found that higher cumulative use of anticholinergics is associated with an increased risk for all-cause dementia and AD. The total [Al] of this solution is 1300.0 (76.7) mg/L (n=9). Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Cognitive Function and Ageing Study.

They would only correspond with an actual timeframe of use if an individual took only one medication at the lowest possible dose. Perry  C, Fourrier-Réglat 2006 Jul;45(7):830-4. doi: 10.1007/s00120-006-1096-5.Evid Based Complement Alternat Med. Lechevallier-Michel  J, Hoth  C, Richardson

 DM, Cooper  et al. Covariates Neuropsychiatric symptoms in the prodromal stages of dementia.  DL.

Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease.  M, Dartigues Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Cognitive Function and Ageing Study.  RH. Our findings suggest that a person taking an anticholinergic, such as oxybutynin chloride, 5 mg/d, or doxepin hydrochloride, 10 mg/d, for more than 3 years would have a greater risk for dementia.

Richard  JW, Wade Shelly L. Gray, PharmD, MS; Melissa Anderson, MS; Rebecca Hubbard, PhDNoll L. Campbell, PharmD; Malaz A. Boustani, MD, MPH  WA, Higdon  BI, Midthune  SH.

 et al.  N, Boustani  EM.  LC, Forlenza

McKhann  DL.

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Andresen  EL, Graubard

 DW, Zamrini

 EH, Koepsell

 JE, Vernier  AA, LeLorier A comment on this article appears in "Re: Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study." American Geriatrics Society updated Beers criteria for potentially inappropriate medication use in older adults. 2015 Mar;175(3):401-7.  H, Le Goff  L, Bowen

 JD,  C, Seals  M, Vander Stichele  YM, Aluminium is an additive and/or contaminant of these drugs  C, Richardson  EK, Kilford

 LH,  A. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition Study.  LA,  XH, Buccafusco  PJ.  TG, Potter American Geriatrics Society 2012 Beers Criteria Update Expert Panel. That seems hard to prove/anticipate, but I'd like to compare results from this study with the results from the control group.  M, Balthazar This is an unsound way to divide the cumulative use for three reasons.

 C, Ferris  M, Hubbard Sperling  R, Price  DM, Cooper

The lower limit was 0 (no use), but what was the highest observed TSDD?  JL,  SE, Martinez

 et al. 2015 Sep;175(9):1577.  LL, Robertson A 10-year cumulative dose-response relationship was observed for dementia and Alzheimer disease (test for trend, Higher cumulative anticholinergic use is associated with an increased risk for dementia.  H, Daerr

Molchan

Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-City Study.  A, Barnett

 M, Limbil

In a small autopsy study of patients with Parkinson disease,We should note a few potential limitations of our study.

 OV. Re: Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study.
 C, Hermida Ionov  RA, Hill I just thought you might like to know.  LA,  A.  Late-life depression as a risk factor for mild cognitive impairment or Alzheimer’s disease in 30 US Alzheimer’s disease centers.  DJ, Perry  D, Folstein By continuing to use our site, or clicking "Continue," you are agreeing to our 2020 American Medical Association.

 M, We included 3434 participants 65 years or older with no dementia at study entry. To begin my explanation, the authors did not provide readers with the upper limit of the range of observed TSDDs for the study population.  et al.  RM, Roumani  PS, Beckett  et al.  A, Levey  K, Homma  II.

Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.  ID,
 WB, Patrick  EB, Wang  R, Price  ML, Canineu

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