Clopidogrel resistance is a condition in which the drug clopidogrel is less effective than normal in people who are treated with it.

COVID-19 is an emerging, rapidly evolving situation. Like many medicines, how well the medicine works and side effects are different from person to person. The aim of this study was to determine relationship between CYP2C19 genotype and FD subtype patients(host factor) with antibiotic resistant strains of H. pylori infection and CagA genotype(bacterial factor). Like many medicines, how well the medicine works and side effects are different from person to person. One-year follow-up was completed in 559 patients. Conclusions: PDS, CYP2C19 RM genotype and CagA 2a gene of H. pylori infection were the predominant type of FD in Thailand. There were 33 patients with EPS and 60 patients with PDS. 2014 Jun 7;20(21):6400-11. doi: 10.3748/wjg.v20.i21.6400.Kuo CH, Lu CY, Shih HY, Liu CJ, Wu MC, Hu HM, Hsu WH, Yu FJ, Wu DC, Kuo FC.World J Gastroenterol. It doesn't break down a drug as completely as a normal metabolizer, which means you might require a lower dose.

n/a Ensembl ENSG00000165841 n/a UniProt P33261 n/a RefSeq (mRNA) NM_000769 n/a RefSeq (protein) NP_000760 n/a Location (UCSC) Chr 10: 94.76 – 94.86 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. Differences in your DNA that make u… One of the reasons why this happens is because of differences in how well CYP2C19 works in each person.The CYP2C19 enzyme processes (metabolizes) medicine to remove them from the body. During the follow-up period, 69 patients (13.3%) experienced adverse cardiovascular events (1 cardiac death, 9 myocardial infarction and 59 unstable angina). There are many medications that are metabolized by CYP2C19.  Some medications such as voriconazole are metabolized to inactive forms that are more easily removed from the body.  Other medications, like clopidogrel, need activation by CYP2C19 to be effective. Many people have CYP2C19 enzyme that works well and have no trouble metabolizing medications.  One way to process the medicine is for enzymes (proteins in the body) to change or break down the medicine.

In patients who have a gene of reduced activity, clopidogrel may not be metabolized to its biologically active form and therefore not achieve pharmacological effect in the body. When people in these groups take normal doses of medications that are metabolized by CYP2C19, they may not see the wanted effect of the medication, experiencing either treatment failure or side effects.Genes, which are made up of DNA, are a set of instructions that act like blueprints and tell our bodies how to grow and work. 2016;17(4):1903-7. doi: 10.7314/apjcp.2016.17.4.1903.World J Gastroenterol. Saving children. Name must be less than 100 characters St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3).If you speak another language, assistance services, free of charge, are available to you.

Clopidogrel (brand name Plavix®) is used to prevent heart attack and stroke in persons who have recently had a heart attack, stroke, or blood circulation disease (peripheral vascular disease). 2011 Apr;26 Suppl 3:46-8. doi: 10.1111/j.1440-1746.2011.06652.x.Asian Pac J Cancer Prev. In particular, CYP2C19 is integral for the generation of the active form of clopidogrel (Plavix®), which is prescribed in a prodrug form. Like many medicines, how well the medicine works and side effects are different from person to person.   CYP2C19 drug metabolism is variable among individuals. It is the opposite for CYP2D6 (to be discussed in a future issue), in which Caucasians are more likely to be deficient than Asians. In intermediate metabolizer (IM), CagA2a genotype was significant higher in PDS than EPS(100% vs.25%; P=0.004).

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