The formulation of claim 27, wherein the potassium sorbate is an amount of about 0.5% by weight.29. Taking a stimulant together with cough medicine can increase your risk of unpleasant side effects.Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. The formulation of claim 2, wherein the aqueous environment is acid conditions in the human stomach or upper small intestine.4. 60/287,992, entitled “Sustained Release Formulations for Nifedipine and Dextromethorphan,” naming Brian C. Keller as an inventor.

Read the label of any other medicine you are using to see if it contains dextromethorphan.

The soft elastic capsule (SEC) is a soft, globular, gelatin shell somewhat thicker than that of hard gelatin capsules. Disclosed herein are sustained release formulations of nifedipine and dextromethrophan that are compatible with a soft elastic gelatin capsule and a two-piece hard shell gelatin capsule. (Maitani Y., J Pharm Sc 85(4): 440-445 (1996)).[0010] Pharmaceutical challenges associated with administering liposomes orally include pH of the stomach, bile salts and digestive enzymes, primarily lipases.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Be ready to tell or show what was Significant antibody response was elicited after oral administration of liposome-entrapped snake venom (enzymes and peptides) compared to no response from free venom. The formulation of claim 1 which comprises a lipophilic compound in an amount between about 0.001% by weight to about 5% by weight.14.

Dextromethorphan is contained in many combination medicines available over the counter. However there is evidence of the observation of multilamellar liposomes dating back to 1911. It has been discovered that specific lipids in the formulations can spontaneously form multilamellar liposomes upon introduction of the formulation to an aqueous environment. The lipid is sometimes glyceryl dioleate or glyceryl dimyristate, and often the lipid is conjugated with polyethylene glycol (PEG), the latter being referred to herein as a “PEG-lipid.” Many forms of PEG are known in the art and many procedures for conjugating PEG to a lipid are also known. Publication: 2002-11-07.

Sustained release formulations for nifedipine dextromethorphan, and danazol. The formulation of claim 1, wherein the PEG-lipid is in an amount between about 50% by weight to about 95% by weight.11.


U.S. patents and other publications referenced herein are hereby incorporated by reference.1. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, Disclosed herein are sustained release formulations of nifedipine and dextromethorphan that are compatible with a soft elastic gelatin capsule and a two-piece hard shell gelatin capsule. Call your doctor for medical advice about side effects. Increased bioavailability of liposomally encapsulated superoxide dismutase (Regnault C., et al., Biopharm & Drug Disp 17,165-174 (1996)) a potent antioxidant used in the treatment of radiation-induced fibrosis, which is poorly absorbed orally, from 14% (free) to 57% with liposomes having ceramides. Dextromethorphan; Quinidine: (Moderate) ... Danazol increases circulating levels of C1 INH and therby increases C4 of the complement system, which also is deficient in hereditary angioedema. This group comprises a large number of preparations, most of which are combined preparations. The discovery of liposomes has been credited to Alec Bangham, a British biologist and physician, who first described swollen lipid particles in the early 1960's. Tell your

Dextromethorphan is often formulated in an amount between about 1% by weight and 10% by weight, and sometimes in an amount of about 5% by weight.
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The formulation of claim 1, wherein the PEG-lipid is in an amount between about 80% by weight to about 95% by weight.12. The unbuffered pH of the stomach can range from 1.5 to 2.5 and causes chemical instability of the liposome membrane surface.

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