The best choice for your GERD symptomsAcid reflux friendly recipe: Creamy zucchini quicheNew research: PPIs increase the risk of collagenous colitis Galati et al. If a physician or pharmacist considers that the PPI use is inappropriate for a particular patient or needs to be stopped (for adverse reactions), s/he may choose from a variety of other gastroenterological products with minimal risk to the central nervous system. Then other molecules (Table The use of PPI within approved indications is quite broad: treatment of gastric and duodenal ulcers and esophageal reflux disease. (Based on published concerns about the possible association between the PPI use and dementia development, a team of Taiwanese scientists (The opposite view on this issue was provided by the study of Booker et al. Visualization of the association of PPI use and incident dementia as survival function is given in Figure 2. These may include weight loss, avoiding tobacco or a change in your eating patterns. Some articles testify the possibility of delirium after PPI (The findings of most research studies described above indicate that there is a direct association between the onset of dementia and depression on one side and the long-term use of PPIs on the other.Although the mechanism of action of the PPI use in dementia is not that clear, one of the factors can be deficiency of vitamin BThe findings about the association of the PPI use and the onset of dementia were also confirmed in a systematic review by Batchelor et al. The research studies were selected on the basis of research topics. While PPIs are known to effectively treat these conditions, they have received negative publicity in recent years as research has associated PPIs with several adverse outcomes. A US study1 has not confirmed earlier reports that proton pump inhibitor (PPI) use is linked to an increased risk of dementia and Alzheimer’s disease.2 In contrast, the latest study, published in the Journal of the American Geriatrics Society ,1 found that continuous or intermittent PPI use was associated with a lower risk of cognitive decline. The latest possible alternative to PPI may be surgical intervention, e.g., various types of fundoplications.MN, BK, and MV equally contributed to the drafting, analyses and final version of the whole manuscript. At the same time, with alternative prescriptions, the patient should be advised about a change in lifestyle (e.g., limit smoking or stop it, weight reduction, regular exercise, wear loose clothing, eat 5 to 6 small portions food, or sleep on the left side). Some of these concerns include hypergastrinemia, development of pneumonia, dementia, and drug interactions. As a result, a group of patients who had long-term PPI (n = 2,950; mean [SD] age, 83.8 [5.4] years, 77.9% female) compared to patients who did not use PPI (n = 70 729; mean [SD] age, 83.0 [5.6] years; 73.6%female) had a significantly increased risk of dementia (HR = 1.44 [95% CI, 1.36–1.52]; P < 0.001). They affect approximately between 5 and 7% of the world's older population (Therefore, there is effort to prevent these mental and neurological disorders in order to reduce economic burden and maintain the quality of life of these elderly people. This content is provided for informational purposes only and should not be used as a replacement for direct medical advice from your healthcare provider. They looked carefully at the all the available studies that have been published that have associated long-term PPI use with complications. (In conclusion, it should be added that the PPI therapy is not the only existing solution. (The situation in the field of neuropsychiatric undesirable effects (specifically depression) after the use of PPI in the elderly population was described by Laudisio et al. The study did not differentiate between dementia subtypes, such as Alzheimer's disease or vascular dementia. In recent years, there have been a few contradictory studis of absolute safety, especially in patients, who have long been using PPIs. See shortly, medical research over the last several years has found additional serious concerns about these medications... Reason for your prescription, the data differs even in this respect RefluxMD and its medical advisors have published! Treat a diagnosed medical condition relevant articles that may reduce or eliminate the need for PPIs a! And stomach acid production new research should provide some reassurance to individuals who require these highly effective medications long-term... 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