Isoket should not be used in the treatment of cardiogenic shock (unless some means of maintaining an adequate diastolic pressure is undertaken), hypertrophic obstructive cardiomyopathy, constrictive pericarditis or cardiac tamponade.Phosphodiesterase type-5 inhibitors (e.g.
En outre aider à réduire la pression.
Isosorbide dinitrate should only be used in pregnancy and during lactation if, in the opinion of the physician, the possible benefits of treatment outweigh the possible hazardsAs for other drugs which produce changes in blood pressure, patients taking Isoket should be warned not to drive or operate machinery if they experience dizziness or related symptoms.During administration of Isoket the following undesirable effects may be observed:Nervous system disorders: headache, dizziness, somnolence.Cardiac disorders: tachycardia, angina pectoris aggravated.Vascular disorders: orthostatic hypotension, collapse (sometimes accompanied by bradyarrhythmia and syncope).Gastrointestinal disorders: nausea, vomiting, heartburn.Skin and subcutaneous tissue disorders: allergic skin reactions (e.g. Each 50 ml bottle also contains 177 mg (7.7 mmol) sodium (as sodium chloride).Isoket is indicated in the treatment of unresponsive left ventricular failure secondary to acute myocardial infarction, unresponsive left ventricular failure of various aetiology and severe to unstable angina pectoris.Isoket is indicated during percutaneous transluminal coronary angioplasty to facilitate prolongation of balloon inflation and to prevent or relieve coronary spasm. • General procedures in the event of nitrate-related hypotension:- The patient must be laid down with lowered head and raised legs- Specific shock treatment (admit patient to intensive care unit)
The rate of formation of the metabolites has been calculated for isosorbide-5-mononitrate (IS-5-MN) with 0.57hAcute toxicity of isosorbide dinitrate was related to an exaggerated pharmacodynamic effect. Further doses may be given not exceeding 5mg within a 30 minute period. Additional information about Isoket.
rash), flush, angioedema, Stevens-Johnson-Syndrome, in single cases: exfoliative dermatitis.General disorders and administration site conditions: astheniaSevere hypotensive responses have been reported for organic nitrates including nausea, vomiting, restlessness, pallor, and excessive perspiration.During treatment with Isoket a temporary hypoxemia may occur due to a relative redistribution of the blood flow in hypoventilated alveolar areas. Isoket Indication: For the prevention of angina pectoris due to coronary artery disease. During isosorbide dinitrate biotransformation nitrite ions are released, which may induce methaemoglobinaemia and cyanosis with subsequent tachypnoea, anxiety, loss of consciousness and cardiac arrest. Les effets indésirables se manifestent le plus souvent par des céphalées sévères et des vertiges.
• Methaemoglobinaemia has been reported in patients receiving other organic nitrates. The usual dose is 1mg given as a bolus injection prior to balloon inflation.
Therefore, Isoket must not be given to patients receiving phosphodiesterase-5 inhibitors (see section 4.5).Isoket should be used with caution and under medical supervision in patients who are suffering from:The development of tolerance (decrease in efficacy) as well as cross tolerance towards other nitrate-type drugs (decrease in effect in case of a prior therapy with another nitrate drug) has been described.
C'est un agent antiangineux du groupe des nitrates organiques. When suggestions are available use up and down arrows to review and ENTER to select. - Reduction therapy of choice with vitamin C, methylene-blue, or toluidine-blueIn case of signs of respiratory and circulatory arrest, initiate resuscitation measures immediately.ATC Code: C02D A 08 Vasodilators used in cardiac diseases.Isosorbide dinitrate is an organic nitrate, which in common with other cardioactive nitrates, is a vasodilator. Animal studies showed good local tolerability of the undiluted isosorbide dinitrate solution.In chronic oral toxicity studies in rats and dogs, toxic effects including CNS symptoms and an increase in liver weight, were observed at exposures considered sufficiently in excess of the maximum human exposure levels indicating little relevance to clinical use.There is no evidence from animal studies suggesting a teratogenic effect of isosorbide dinitrate. Par la présence de dinitrate d'isosorbide dans leur composition, il est possible d'isoler de telles préparations: Comme déjà mentionné, Isoket est un agent antiangineux et son principe actif, le dinitrate d'isosorbide, a un effet vasodilatateur. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Ce médicament est souvent utilisé dans le traitement des maladies SSS comme agent antiangineux. • Raise the blood pressure if the blood pressure is very low. WebMD provides common contraindications for Isosorbide Dinitrate Sublingual. Pour la prévention et le traitement des maladies cardiovasculaires, nos lecteurs conseillent le médicament "NORMALIFE".C'est un remède naturel qui affecte la cause de la maladie, en empêchant complètement le risque de faire une crise cardiaque ou un accident vasculaire cérébral.
Further information.
Le dinitrate d'isosorbide( aka dinitrate d'isosorbide) est la substance active de la préparation.
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