You may report side effects to FDA at 1-800-FDA-1088.Taking isosorbide dinitrate with certain other medicines can cause severely low blood pressure. Each isosorbide dinitrate sublingual tablet contains 2.5 mg or 5 mg of ISDN. SL (prophylaxis): 2.5-5 mg 15 minutes before performing activities likely to cause angina. Clearance is affected primarily by denitration to the 2-mononitrate (15 to 25%) and the 5-mononitrate (75 to 85%).Both metabolites have biological activity, especially the 5-mononitrate. Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is:and whose molecular weight is 236.14. Ask your doctor before using any headache pain medication.Common side effects may be more likely to occur, such as:This is not a complete list of side effects and others may occur. This includes medicine to treat erectile dysfunction or Tell your doctor about all your current medicines and any you start or stop using, especially:This list is not complete. If you are on a schedule, take the missed dose as soon as you remember. 40 aluminium lake.

Anti-anginal activity is present about 1 hour after dosing.Most controlled trials of multiple-dose oral ISDN taken every 12 hours (or more frequently) for several weeks have shown statistically significant anti-anginal efficacy for only 2 hours after dosing. Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.Each Isosorbide Dinitrate Tablet, USP contains 5 mg, 10 mg, or 20 mg of Isosorbide dinitrate.The principal pharmacological action of Isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Do not chew or swallow it.You may use the sublingual tablet within 15 minutes before an activity you think might cause chest pain. These headaches may gradually become less severe as you continue to use nitroglycerin. If you use too much isosorbide dinitrate, it might stop working as well in controlling your condition.Try to rest or stay seated when you take this medicine (may cause To prevent angina attacks, isosorbide dinitrate is usually taken at regular intervals.To treat an angina attack that has already begun, use the medicine at the first sign of chest pain. This effect may be more frequent in patients who have also consumed alcohol.The vasodilating effects of Isosorbide dinitrate may be additive with those of other vasodilators. Ask your pharmacist if you have any questions about the new kind of isosorbide dinitrate you receive at the pharmacy.Seek emergency medical attention if your chest pain gets worse or lasts longer than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded.You may have very low blood pressure while taking this medicine. Tell your doctor if you are pregnant or plan to become pregnant.It is not known whether isosorbide dinitrate passes into breast milk or if it could affect the nursing baby. 40 mg, round, light green tablets imprinted "BPI 192" on one side and deeply scored on reverse side: NDC 0187-0192-01, bottles of 100. Isordil ® (isosorbide dinitrate) Oral Titradose ® Tablets are available as follows: 5 mg, round, pink tablets imprinted "BPI 152" on one side and deeply scored on reverse side: NDC 0187-0152-01, bottles of 100. 2.5 mg – 10 mg di bawah lidah (sublingual) Dosis ISDN untuk gagal jantung kongestif. In a modified two-litter reproduction study, there was no remarkable gross pathology and no altered fertility or gestation among rats fed Isosorbide dinitrate at 25 or 100 mg/kg/day.At oral doses 35 and 150 times the maximum recommended human daily dose, Isosorbide dinitrate has been shown to cause a dose-related increase in embryotoxicity (increase in mummified pups) in rabbits.

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