slow platelet destruction through a blocking of the Fc receptors of the Mil Med 2000;165(7 suppl 2):43–5Adapted with permission from Hawkes CA. for myelosuppression. In addition, the every 12 hours dosing schedule improves compliance. Mil Med 2000;165(7 suppl 2):43–5Reproduced with permission from Hawkes CA. occurs, the Fab portion of immunoglobulin G (IgG) antibodies binds to this Pharmacia Corporation: Peapack, N.J.: April 18, 2000Reproduced with permission from Zyvox (linezolid) approved as super antibiotic, new treatment option for hospital-acquired and drug-resistant bacteria. The Fc portion of that IgG antibody Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). Peapack, N.J.: Pharmacia & Upjohn. Chien JW, Interscience Conference on Antimicrobial Agents and Chemotherapy: 39th annual meeting, San Francisco, CA, Sept. 26–29, 1999. Oxazolidinones: a review. Intravenous linezolid at twice daily dosages of 600 mg produced a clinical cure rate of 88.6 percent compared with 73.7 percent in the patients with vancomycin-resistant enterococcus infections who received 200 mg daily.Community-acquired pneumonia, including concurrent bacteremiaCommunity-acquired pneumonia, including concurrent bacteremiaResults from a compassionate use trial involving treatment of patients with bacteremia for resistant, gram-positive infections reveal that linezolid was well tolerated.Eighty-one patients with community-acquired pneumonia were treated with linezolid, resulting in a 98 percent cure rate.Linezolid (600 mg twice a day) and vancomycin (1 g twice a day) are similarly safe and efficacious in the treatment of patients with nosocomial pneumonia, including methicillin-resistant Nausea, vomiting, thrombocytopenia (2.4 percent), myelosuppressionIV = 143.74; tablet = 106.26 (600 mg every 12 hours)Inhibits protein synthesis at elongation step, similar to aminoglycosides, clindamycin (Cleocin), and chloramphenicol (Chloromycetin).Phlebitis, arthralgias/myalgias, hyperbilirubinemia (25 percent)Similar site of inhibition may allow cross-resistance between Q/D, aminoglycosides, clindamycin, and chloramphenicol.Broader FDA indications may allow clinicians to feel more comfortable prescribing linezolid.Allows opportunity for conversion to oral therapy for outpatient treatment with linezolidNausea, vomiting, thrombocytopenia (2.4 percent), myelosuppressionIV = 143.74; tablet = 106.26 (600 mg every 12 hours)Inhibits protein synthesis at elongation step, similar to aminoglycosides, clindamycin (Cleocin), and chloramphenicol (Chloromycetin).Phlebitis, arthralgias/myalgias, hyperbilirubinemia (25 percent)Similar site of inhibition may allow cross-resistance between Q/D, aminoglycosides, clindamycin, and chloramphenicol.Broader FDA indications may allow clinicians to feel more comfortable prescribing linezolid.Allows opportunity for conversion to oral therapy for outpatient treatment with linezolidLinezolid therapy has been found to cure or improve more than 90 percent of patients treated for skin and soft tissue infections.Quinupristin/dalfopristin (Synercid) was recently approved by the FDA for the treatment of patients with vancomycin-resistant The oxazolidinones is a new class of antibiotics that are effective against many resurgent gram-positive organisms.
Linezolid, Zyvox, Thrombocytopenia, Drug Induced Thrombocytopenia, Linezolid Induced Thrombocytopenia This will depend on how responsibly and frequently linezolid is prescribed and how quickly bacteria can evolve a new defense. PAUL W. AMENT, PHARM.D., NAMIRAH JAMSHED, M.D., and JOHN P. HORNE, M.D., Latrobe Area Hospital, Latrobe, Pennsylvania.While the choices available for the management of gram-positive, drug-resistant bacterial infections are becoming limited, antimicrobial resistance is becoming increasingly problematic because of the widespread overuse of antibiotics.
Their widespread and unnecessary use is the greatest contributing factor. Linezolid (Zyvox) is a synthetic oxazolidinone antimicrobial agent that has been known to cause thrombocytopenia. Formulary Monograph Service. Thus far, it has demonstrated activity against all clinically significant, gram-positive bacteria. Jones RN. The introduction of penicillin in 1944 was soon followed by reports of resistance to Multiple factors contribute to the development of resistance to antibiotics.

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