National Institutes of Health Office of Medical Applications of Research.
Clofibrate and niacin in coronary heart disease. 58. Nye ER, Sutherland NHF, Temples WA. Gemfibrozil is primarily eliminated by metabolism and drug clearance may be decreased in patients with hepatic impairment. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Adult Treatment Panel III Report. Gemfibrozil increases the activity of extrahepatic Gemfibrozil was selected from a series of related compounds synthesized in the laboratories of the American company InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid 127. Gemfibrozil—a new lipid lowering agent. O’Brien JR, Etherington MD, Shuttleworth RD et al. Common side effects include headache, dizziness, feeling tired, and intestinal upset.Gemfibrozil was patented in 1968 and came into medical use in 1982.The exact mechanism of action of gemfibrozil is unknown; however, several theories exist regarding the very low density lipoprotein (VLDL) effect; it can inhibit lipolysis and decrease subsequent hepatic fatty acid uptake as well as inhibit hepatic secretion of VLDL; together these actions decrease serum VLDL levels and increase HDL-cholesterol; the mechanism behind HDL elevation is currently unknown. Available for Android and iOS devices. 89.
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Adjunct to dietary therapy to reduce the risk of developing CHD in patients with type IIb hyperlipoproteinemia without clinical evidence of CHD (primary prevention) who have an inadequate response to dietary management, weight loss, exercise, and drugs known to reduce LDL …
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Consensus Conference: lowering blood cholesterol to prevent heart disease. The lipid research clinics coronary primary prevention trial results: part II. The effect of gemfibrozil on serum lipids in diabetic patients. 49. 66. Hoeg JM, Gregg RE, Brewer HB. 32. 61. Gemfibrozil (lopid, lopid) 300 mg, the recommended starting dose for is one 50mg tablet taken 1 hour before sexual activity. Janus ED, Costa D, Ononogbu IC et al. Glueck C. Influence of gemfibrozil on high-density lipoproteins. Rasi VPO, Torstila I. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study (4S).
Nikkila EA, Ylikahri R, Huttunen JK. CI-719 in hyperlipoproteinaemia: interim data. Schwandt P, Weisweiler P, Neureuther G. Serum lipoprotein lipids after gemfibrozil treatment. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1985: 457.4.
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Eisalo A, Manninen V. Gemfibrozil and clofibrate in the treatment of hyperlipidaemias: a comparative trial. Effect of gemfibrozil upon platelet function and blood coagulation. Dahlen D, Gillnas T, Borresen AL et al. In patients with biliary cirrhosis, further elevations of serum cholesterol can occur. Quantitative stereology of peroxisomes in hepatocytes from hyperlipoproteinemic patients receiving gemfibrozil. Hall MJ, Nelson LM, Russell RI et al. Howard AN, Ghosh P. Gemfibrozil treatment: a comparison with clofibrate. We comply with the HONcode standard for trustworthy health information -
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