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Both saxagliptin and alogliptin can increase the risk of hypoglycaemia.
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Available from: URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM460038.pdf." Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
117853-overview
Peripheral edema was more commonly reported in patients treated with the combination saxagliptin and thiazolidinedione.
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The possibility of pharmacokinetic interactions may occur as the two drugs are metabolized by hepatic CYP3A4 and their co administration may affect their plasma concentrations.
Active ingredient Sildenafil Citrate increases the body's ability to achieve and maintain an erection during sexual stimulation; active ingredient Dapoxetine helps to delay the premature ejaculation. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information -
The possibility of pharmacokinetic interactions may occur as the two drugs are metabolized by hepatic CYP3A4 and their co administration may affect their plasma concentrations. Drugs Affecting Hepatic Microsomal Enzymes .
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Very common (10% or more): Hypoglycemia
Early development was solely by Bristol-Myers Squibb; in 2007 AstraZeneca joined with Bristol-Myers Squibb to co-develop the final compound and collaborate on the marketing of the drug.. /viewarticle/937067
Controlled studies in pregnant women show no evidence of fetal risk.Dipeptidyl peptidase IV (DPP-4) inhibition that results in increased incretin hormones and enhanced glycemic controlPeak plasma time: 2hr (saxagliptin); 4 hr (5-hyroxy saxagliptin)Hepatic by CYP450 3A4/5 to active metabolite (50% potency of parent compound)Half-life (elimination): 2.5 hr (saxagliptin); 3.1 hr (5-hydroxy saxagliptin)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Very common (10% or more): Hypoglycemia "Product Information.
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Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. In Vitro Assessment Of Drug Interactions.
Saxagliptin has the following interaction information: Acarbose.
and formulary information changes. Currently, there are no documented drug-drug interactions associated with dapoxetine.
Saxagliptin 5 mg once/day will be given from day 9 till day 12, then on day 13 the two drugs will be co-administered.
the aim of work is to investigate the effect of sildenafil a CYP3A4 substrate and inhibitor on the pharmacokinetics and safety of Saxagliptin, a CYP3A4 substrate Subjects and Methods: Eighteen healthy volunteers will be recruited in Sequential, single center study to determine pharmacokinetic parameters of Saxagliptin, and sildenafil,(AUC0→∞), (AUC0→t); Cmax; tmax; t½, k; ka) will be measured using validated LC-MS/MS method.
Severity of interaction:
2001
Apalutamide is predicted to moderately decrease the exposure to saxagliptin. ([2015, Aug 28]):Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported.
Medscape - Diabetes mellitus type 2 dosing for Onglyza (saxagliptin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Saxagliptin, sold under the brand name Onglyza, is an oral hypoglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
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Contact the applicable plan 2002
Applies to saxagliptin: oral tablet.
1. also increases fetal risk for major malformations and macrosomia related morbidityThere is no information regarding presence of metformin or alogliptin in human milk, effects on breastfed infant, or effects on milk production; limited published studies report that metformin is present in human milk; however, there is insufficient information to determine effects of metformin on breastfed infant and no available information on effects of metformin on milk production; the developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from underlying maternal conditionA: Generally acceptable.
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