Fluticasone nasal (nose) spray is a steroid nasal spray for cold-like symptoms caused by allergic rhinitis.This is inflammation of the inside of your nose that can be from hay fever.. Fluticasone is a type of medicine called a steroid (or corticosteroid).Corticosteroids are a copy of a … After intranasal treatment of patients with rhinitis for 3 weeks, fluticasone propionate plasma concentrations were above the level of detection (50 pg/mL) only when recommended doses were exceeded and then only in occasional samples at low plasma levels.Following intravenous administration, the initial disposition phase for fluticasone propionate was rapid and consistent with its high lipid solubility and tissue binding. Children 4 years of age and older—At first, 1 spray in each nostril once a day.

The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin, conivaptan, lopinavir, nefazodone, voriconazole) with Flonase Nasal Spray is not recommended because increased systemic corticosteroid adverse effects may occur.A drug interaction trial with fluticasone propionate aqueous nasal spray in healthy subjects has shown that ritonavir (a strong CYP3A4 inhibitor) can significantly increase plasma fluticasone propionate exposure, resulting in significantly reduced serum cortisol concentrations Coadministration of orally inhaled fluticasone propionate (1,000 mcg) and ketoconazole (200 mg once daily) resulted in a 1.9-fold increase in plasma fluticasone propionate exposure and a 45% decrease in plasma cortisol area under the curve (AUC), but had no effect on urinary excretion of cortisol.Hepatic impairment: Monitor patients for signs of increased drug exposure.

Such infants should be carefully monitored.It is not known whether fluticasone propionate is excreted in human breast milk. Monitor patients periodically for signs of adverse effects on the nasal mucosa. Thus, no statistically significant effect on growth was noted compared with placebo. Therefore, close monitoring is warranted in patients with a change in vision or with a history of increased intraocular pressure, glaucoma, and/or cataracts.Hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria, contact dermatitis, and rash) have been reported after administration of Flonase Nasal Spray. The exact number and precise mechanism are unknown. From the primary population receiving Flonase Nasal Spray (n = 56) and placebo (n = 52), the point estimate for growth velocity with Flonase Nasal Spray was 0.14 cm/year lower than placebo (95% CI: -0.54, 0.27 cm/year). This can happen when you stop taking oral corticosteroid medicines (such as prednisone) and start taking medicine containing an inhaled steroid (such as Flonase Nasal Spray). Shake Flonase Nasal Spray gently before each use.Patients should use Flonase Nasal Spray at regular intervals since its effectiveness depends on its regular use. Do not take extra doses or stop taking Flonase Nasal Spray without talking to your healthcare provider.1. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Formal pharmacokinetic trials using Flonase Nasal Spray have not been conducted in subjects with hepatic impairment. [see Warnings and Precautions (5.7), Pediatric Use (8.4)]What should I tell my healthcare provider before using FlonaseNasal Spray?Tell your healthcare provider about all of your health conditions, including if you:Tell your healthcare provider about all the medicines you take,Read the step-by-step instructions for using Flonase Nasal Spray at the end of this Patient Information.What are the possible side effects of Flonase Nasal Spray?Flonase Nasal Spray may cause serious side effects, including:a certain fungal infection in your nose, mouth, and/or throat (thrush).hole in the cartilage of your nose (nasal septal perforation).weakened immune system and increased chance of getting infections (immunosuppressionlowered steroid hormone levels (adrenal insufficiency).The most common side effects of FlonaseNasal Spray include:Keep Flonase Nasal Spray and all medicines out of the reach of children.General information about the safe and effective use of Flonase Nasal Spray.Read this information before you start using your Flonase Nasal Spray.Your Flonase Nasal Spray must be primed before you use it for the first time and when you have not used it for a week or more.Do not try to unblock the nasal applicator by inserting a pin or other sharp object.We comply with the HONcode standard for trustworthy health information - Women should be advised to contact their physicians if they become pregnant while taking Flonase Nasal Spray.Mice and rats at fluticasone propionate doses approximately 1 and 4 times, respectively, the maximum recommended human daily intranasal dose (MRHDID) for adults (on a mg/mIn rabbits, fetal weight reduction and cleft palate were observed at a fluticasone propionate dose approximately 0.3 times the MRHDID for adults (on a mg/mFluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits.Experience with oral corticosteroids since their introduction in pharmacologic, as opposed to physiologic, doses suggests that rodents are more prone to teratogenic effects from corticosteroids than humans. The direct relationship of these findings to long-term symptom relief is not known.The potential systemic effects of Flonase Nasal Spray on the HPA axis were evaluated. If you come in contact with someone who has chickenpox or measles call your healthcare provider right away.

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