Overbosch D, Schilthuis H, Bienzle U, et al. These dreams aren’t real. 23. Considerations for the application of claims of mefloquine intoxication in forensic settings are discussed.Mefloquine is a 4-quinolinemethanol antimalarial first synthesized in the early 1970sTo secure the drug's commercial manufacture and its continued availability, intellectual property rights and research related to mefloquine were transferred at no cost to F. Hoffman-La Roche Ltd. (Roche).Early prelicensure studies on mefloquine were conducted predominantly among male prisoners,The purported safety of mefloquine was so well established that when reports of severe psychiatric side effects, including amnesia, confusion and psychosis, first emerged in the literature following the drug's early European licensure,Use of mefloquine had previously been encouraged among United States overseas diplomatic staffBecause the drug is associated with an increased risk of violenceAccording to the current U.S. mefloquine package insert,Case reports suggest that mefloquine intoxication may begin with a variable prodrome which may present with personality change,It is tempting to speculate that the “more serious event” referenced in the package insert is a euphemism for psychosis. Malaria can be a life-threatening infection. The baby's head was taken clean off and the little girl was dropped dead in an instant. It was Figueroa and Delvalle calling, Marines from my old platoon. Force health protection procedures for deployment and travelResponse to Nevin RL: Mefloquine neurotoxicity and gap junction blockade: critical insights in drug repositioningLariam® (Mefloquine Hydrochloroquine) Medication GuideThe position of mefloquine as a 21st century malaria chemoprophylaxisMefloquine blockade of connexin 36 and connexin 43 gap junctions and risk of suicideSevere neuropsychiatric reaction following mefloquine use (in Spanish)Paranoid psychosis related to mefloquine antimalarial prophylaxisCase study: neuropsychiatric symptoms associated with the antimalarial agent mefloquineMefloquine-induced mania in a 22-year-old Chinese manPsychopathological phenomena in long-term follow-up of acute psychosis after preventive mefloquinine (Lariam) administration (in German)Psychotic episode caused by prevention of malaria with mefloquine: a case reportChildhood mefloquine-induced mania and psychosis: a case reportProlonged visual illusions induced by mefloquine (Lariam): a case reportPanic attack after therapeutic administration of mefloquine (in French)Malaria on the Thai-Burmese border: treatment of 5192 patients with mefloquine-sulfadoxine-pyrimethamineIntermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquineA phase II clinical trial of mefloquine in patients with chloroquine-resistant falciparum malaria in ThailandThrombotic-thrombocytopenic purpura following malaria prophylaxis with mefloquineMood disorder after malaria prophylaxis with mefloquine (two case reports) (in French)Review of central nervous system Adverse events related to the antimalarial drug, mefloquine (1985-1990)Neuropsychiatric disturbances after malaria prophylaxis with mefloquine (in German)Side-effects of the antimalarial mefloquine: presentation of 20 cases (in Spanish)Lariam® (Mefloquine Hydrochloroquine) Medication GuidePamaquine poisoning in man, with a clinicopathologic study of one caseA psychotic episode in a patient coming home from Africa: the possible role of mefloquine (in French)Neuropsychiatric reactions with mefloquine chemoprophylaxisMefloquine-induced psychoses–problems in etiologic classification based on 2 case reports (in German)Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellersSevere psychiatric side effects observed during prophylaxis and treatment with mefloquineEncephalopathy and memory disorders during treatments with mefloquine (in French)Neuropsychiatric intolerance during mefloquine prophylaxis. The insights of the present review also emphasize the critical importance of thoroughly documenting patient education should mefloquine be prescribed, including informing patients of those prodromal symptoms that should compel them to discontinue the medication immediately and seek medical assistance.Our evolving experience with mefloquine raises questions about the potential for lasting behavioral effects from other antimalarial medications, including those presently under development,The authors thank Ms. Danielle Feldman, MSPH, of the Henry M. Jackson Foundation, for her assistance in directing the authors to many of the manuscripts referenced in this report, and Sergeant First Class Georg-Andreas Pogány, U.S. Army (Retired), for his helpful review of the vignette and for his efforts in helping to raise awareness of the concerns referenced in this report.Disclosures of financial or other potential conflicts of interest: Dr. Nevin has served as paid and Thank you for your interest in recommending The Journal of the American Academy of Psychiatry and the Law site.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.

25. Inside was a family. I pulled it from a drawer and answered.

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