Cytovene is available in genericform. Discard any unused portion of the reconstituted solution.a) Based on patient weight, the appropriate volume of the reconstituted solution (ganciclovir concentration 50 mg/mL) should be removed from the vial and added to an acceptable infusion fluid (typically 100 mL) for delivery over the course of 1 hour. The contents of the vial should be prepared for administration in the following manner:a) Reconstitute lyophilized Cytovene-IV by injecting 10 mL of sterile water for injection, USP, into the vial.
Similarly, men should be advised to practice barrier contraception during and for at least 90 days following treatment with Cytovene-IV Animal data indicate that ganciclovir is mutagenic and carcinogenic. IV affects QTc less than oral; proarrhythmia infrequent.
Do not skip any doses or stop using this medication even for a short time unless directed to do so by your doctor. The transmission of CMV to the fetus is a result of maternal viremia and transplacental infection. CYTOVENE-IV is supplied in cartons of 5 single-dose vials (NDC 61269-450-20). Before you begin treatment with ganciclovir, you and your doctor should talk about the good this medicine will do as well as the risks of using it.Ganciclovir is to be administered only by or under the supervision of your doctor.In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. It is incompatible with Cytovene-IV and may cause precipitation.b) Gently swirl the vial in order to ensure complete wetting of the product.
Monitoring renal function during therapy with Cytovene-IV is essential, especially for elderly patients and those patients receiving concomitant agents that may cause nephrotoxicity Cytovene-IV may cause fetal toxicity when administered to pregnant women based on findings in animal studies. These resistant isolates were associated with subsequent treatment failure for retinitis.The possibility of viral resistance should be considered in patients who show poor clinical response or experience persistent viral excretion during therapy.Cross-resistance has been reported for amino acid substitutions selected in cell culture by ganciclovir, cidofovir or foscarnet. The pKCytovene-IV (ganciclovir), formulated as monosodium salt, using sodium hydroxide as a salt forming agent, is a sterile white to off-white lyophilized powder. Advise patients to have frequent ophthalmological follow-up examinations while being treated with Cytovene-IV.
One or more of the following adverse reactions has been reported with overdoses:Since ganciclovir is dialyzable, dialysis may be useful in reducing serum concentrations in patients who have received an overdose of Cytovene-IV Cytovene-IV contains ganciclovir, in the form of the sodium salt for intravenous injection. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Propafenone : Definite . It is also used to help prevent CMV infection in patients who receive organ or bone marrow transplants, as well as in patients with advanced human immunodeficiency virus (HIV) infection. Alcohol or To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Older adults may be at greater risk for kidney problems while using this drug.Some products that may interact with this drug include: didanosine, If someone has overdosed and has serious symptoms such as passing out or If you miss a dose, use it as soon as you remember. All rights reserved. It is used to treat infections caused by viruses.Ganciclovir is used to treat the symptoms of cytomegalovirus (CMV) infection of the eyes in people whose immune system is not working fully. Ganciclovir can decrease bone marrow function. Except for histiocytic sarcoma of the liver, ganciclovir-induced tumors were generally of epithelial or vascular origin. 18 CYTOVENE-IV is the brand name for ganciclovir sodium for injection. However, it does not work in treating certain viruses, such as the common cold or the flu.This medicine may cause some serious side effects, including anemia and other blood problems. Mortality in symptomatic infants is about 10% and approximately 50–90% of symptomatic surviving newborns experience significant morbidity, including mental retardation, sensorineural hearing loss, microcephaly, seizures, and other medical problems. If this occurs, there are certain precautions you can take to reduce the risk of infection or bleeding:The use of birth control is recommended for both men and women. Sensitivity test results, expressed as the concentration of drug required to inhibit the growth of virus in cell culture by 50% (ECIn vivo: Viruses resistant to ganciclovir can arise after prolonged treatment or prophylaxis with ganciclovir by selection of substitutions in pUL97 and/or pUL54. For non-prescription products, read the label or package ingredients carefully.Ganciclovir can cause serious side effects in any patient. The last available isolate from each subject was tested for reduced sensitivity, and 2 of 40 were found to be resistant to ganciclovir.
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