The injection formulation is contraindicated in neonates with significant renal impairment.• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. By definition, it is completely efficacious in the treatment of the primary headache disorders paroxysmal hemicrania and hemicrania continua. Indomethacin did not decrease bacterial endotoxin-induced release of endogenous pyrogen in vivo.

Contraindicated in patients who experience bronchospasm, asthma, rhinitis, or urticaria with nonsteroidal anti-inflammatory drug (NSAID) or aspirin therapy.• CNS effects: May cause drowsiness, dizziness, blurred vision, and other neurologic effects, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery, driving). J Clin Invest. Specifically, the risk of acute phosphate nephropathy may be enhanced. Int J Clin Oncol. Management: Discontinue antiplatelet agents prior to initiating enoxaparin whenever possible.

Clin Pharmacol Ther. Management: Drugs listed as exceptions to this monograph are discussed in further detail in separate drug interaction monographs.Deferasirox: Nonsteroidal Anti-Inflammatory Agents may enhance the adverse/toxic effect of Deferasirox. 2001;21(9):928–31.Ghiotto N, Sances G, Di Lorenzo G, Trucco M, Loi M, Sandrini G, et al. Potassium-Sparing Diuretics: Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of Potassium-Sparing Diuretics. Talniflumate: May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents.Tenofovir Products: Nonsteroidal Anti-Inflammatory Agents may enhance the nephrotoxic effect of Tenofovir Products. Both agents may contribute to impaired platelet function and an increased risk of bleeding.

Loop Diuretics may enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. 2009;16(9):968–81.Bendtsen L, Evers S, Linde M, Mitsikostas DD, Sandrini G, Schoenen J. EFNS guideline on the treatment of tension-type headache—report of an EFNS task force. Indomethacin-responsive headache syndromes. Headache may occur; cessation of therapy required if headache persists after dosage reduction.• Hematologic effects: Platelet adhesion and aggregation may be decreased; may prolong bleeding time; patients with coagulation disorders or who are receiving anticoagulants should be monitored closely. Specifically, the risk of bleeding may be increased by concurrent use of these agents.Pentoxifylline: May enhance the antiplatelet effect of Agents with Antiplatelet Properties.Phenylbutazone: May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents.Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Besides, indometacin has logarithmic acid dissociation constant pKa of 3 to 4.5. Nonsteroidal Anti-Inflammatory Agents (Nonselective) may diminish the therapeutic effect of Selective Serotonin Reuptake Inhibitors. 1999;19(2):115–27.Strecker T, Dux M, Messlinger K. Increase in meningeal blood flow by nitric oxide—interaction with calcitonin gene-related peptide receptor and prostaglandin synthesis inhibition. If combined, monitor patients extra closely for signs and symptoms of bleeding.Dasatinib: May enhance the anticoagulant effect of Agents with Antiplatelet Properties. 1998;61(1):2–7.Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Unable to load your delegates due to an error 2009 Sep;9(9):1371-8. doi: 10.1586/ern.09.85.Edvinsson JCA, Viganò A, Alekseeva A, Alieva E, Arruda R, De Luca C, D'Ettore N, Frattale I, Kurnukhina M, Macerola N, Malenkova E, Maiorova M, Novikova A, Řehulka P, Rapaccini V, Roshchina O, Vanderschueren G, Zvaune L, Andreou AP, Haanes KA; European Headache Federation School of Advanced Studies (EHF-SAS).J Headache Pain. Management: Seek alternatives to these combinations whenever possible. Angiotensin II Receptor Blockers: May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. 1983;70(6):1103–5.Roller A, Bahr OR, Streffer J, Winter S, Heneka M, Deininger M, et al. Heparin: Nonsteroidal Anti-Inflammatory Agents may enhance the anticoagulant effect of Heparin. Headache. Clin Pharmacokinet. Effect of COX inhibitors on electrical stimulation induced vasodilation of the middle meningeal… Effect of COX inhibitors on repeated CGRP (0.33 μg kg Effect of COX inhibitors on dural vasodilation, induced by repeated sodium nitroprusside infusions,…

Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: The role of COX-1 and MRP.

Nonsteroidal Anti-Inflammatory Agents may enhance the nephrotoxic effect of Aliskiren. Non-steroidal anti-inflammatory drugs (NSAIDs) that act as cyclo-oxygenase (COX) inhibitors are commonly used in the treatment of a range of headache disorders, although their mechanism of action is unclear. Tiludronate: Indomethacin may increase the serum concentration of Tiludronate. Rivaroxaban: Nonsteroidal Anti-Inflammatory Agents (Nonselective) may enhance the adverse/toxic effect of Rivaroxaban.

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