The etiology and pathogenesis of seborrheic dermatitis is unknown; however, the focus lies on the involvement of Malassezia yeasts or fatty acid metabolites of Malassezia, on hormones and immunologic factors. Assessment of the disease severity was performed at baseline and at weeks 2, 4, and 8. It commonly affects the scalp, face and flexures of the body. Mean percentage decrease in clinical severity scores from baseline to last available visit was 63.4% (95% CI 57.7-69) and 54.4% (95% CI 47.9-61) in the ketoconazole- and metronidazole-treated patients, respectively (P = 0.31). It is closely related to infantile seborrheic dermatitis, or diaper rash. At the final evaluation of the response at 8 weeks, no statistically significant difference was found between the treatment groups (P > 0.05). Conclusion: The diagnosis is usually a clinical one, based on history and the appearance and site of lesions. Peak serum concentrations are quite similar after oral or intravenous administration and average approximately 10 μg/ml after a single 500mg dose. Of the 64 patients, 17 (80%) in the metronidazole group, 21 (100%) in the pimecrolimus group and 22 (100%) in the methylprednisolone aceponate group completed the study.
We suggest pimecrolimus to be a therapeutic option for seborrhoeic dermatitis cases that show an unfavourable response to methylprednisolone aceponate.Seborrheic dermatitis is a recurrent, usually mild, skin disorder with typical clinical manifestations. Forty-four patients with seborrheic dermatitis were enrolled in the study. Retreatment of the disease with pimecrolimus resulted in shorter cure and longer remission times. Despite its frequency, much controversy remains regarding the pathogenesis of SD. ... metronidazole oral brand names and other generic formulations include: Flagyl ER Oral, ... Never use this combination of drugs because of high risk for dangerous interaction. It also often occurs in patients with HIV or neurologic disorders like Parkinson disease or mood disorders. To evaluate if nonprescription topical agents may provide positive outcomes in the management of mild-to-moderate facial seborrheic dermatitis by reducing inflammation and scale production through clinical evaluation and erythema-directed digital photography. Zusammenfassung.
This article reviews the optimal use of topical metronidazole in the treatment of rosacea and other innovative but off-label dermatologic uses reported in the literature.Film dosage forms containing metronidazole (MZ) were prepared from natural polysaccharides, such as pullulan (PUL) or sodium alginate (ALG), without heating or controlling the pH. Side effects were seen only on the first day of the retreatment and an increase in erythema was seen in fewer patients. Additionally, erythema and itching can be present. For the different symptoms combined (scaling, redness, itching, and papules), no significant difference was seen between the two groups when the total scores at week 2 and at week 4 were compared with the initial scores. The study included a total of 64 (32 males and 32 females) consecutive patients with facial seborrhoeic dermatitis.
The release profiles of MZ from the films were investigated.
SD can affect the scalp as well as other seborrheic areas, and involves itchy and flaking or scaling skin, inflammation and pruritus. Retreatment of the recurrence of SD with pimecrolimus as monotherapy is an effective and safe approach in the management of the disease.
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