'Half Sinemet CR': pink-coloured, oval-shaped, biconvex tablets, plain one side and the other marked '601'.Idiopathic Parkinson's disease, in particular to reduce off-period in patients who previously have been treated with levodopa/decarboxylase inhibitors, or with levodopa alone and who have experienced motor fluctuations. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).Abnormalities in various laboratory tests have occurred with carbidopa-levodopa preparations and may occur with 'Sinemet CR' or 'Half Sinemet CR'. Sinemet 10-100. Although the causes of the motor fluctuations are not completely understood, it has been demonstrated that they can be attenuated by treatment regimens that produce steady plasma levels of levodopa.Levodopa relieves the symptoms of Parkinson's disease by being decarboxylated to dopamine in the brain. Patients taking these drugs with 'Sinemet CR' or 'Half Sinemet CR' should be observed carefully for loss of therapeutic response. This normally obviates the necessity for large doses of levodopa at frequent intervals.

The mean peak concentration of levodopa following administration of one 'Half Sinemet CR' tablet was greater than 50% of that following one 'Sinemet CR' tablet. Generally, there was no further improvement of other symptoms of Parkinson's disease.The pharmacokinetics of levodopa following administration of 'Sinemet CR' were studied in young and elderly healthy volunteers. For patients receiving 900 mg/day to 1,000 mg/day of levodopa as immediate-release carbidopa-levodopa, the suggested starting regimen of Sinemet CR is a total of 1,000 mg levodopa in 3 divided doses (e.g., 400 mg in the morning, 400 mg in the afternoon, and 200 mg in the evening). Amber glass bottles or HDPE bottles in packs of 100, 84, or 56 tablets.Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets Sinemet CR 50 mg/200 mg Prolonged-Release Tablets: 5 September 1991/Renewed 16 April 2008Half Sinemet CR 25 mg/100 mg Prolonged-Release Tablets: 7 October 1992/Renewed 16 April 2008 luvox cr maprotiline mirtazapine nefazodone oleptro* paroxetine paroxetine er paxil paxil cr pexeva ... minoxidil moexipril hcl moexipril-hydrochlorothiazide nadolol nadolol-bendroflumethiazide neptazane ... sinemet sinemet cr stalevo tasmar trihexyphenidyl hcl xadago* zelapar phosphate binding agents auryxia page 6 of 7. COMMON BRAND NAME(S): Sinemet CR. Patients who have experienced somnolence and/or an episode of sudden sleep onset must refrain from driving or operating machines. A greater incidence of dyskinesias was seen with 'Sinemet CR' than with 'Sinemet'.Other side-effects that also were reported frequently (above 2%) were: nausea, hallucinations, confusion, dizziness, chorea and dry mouth.Side effects occurring less frequently (1-2%) were: dream abnormalities, dystonia, somnolence, insomnia, depression, asthenia, vomiting and anorexia.Other side effects reported in clinical trials or in post-marketing experience include: Other side effects that have been reported with levodopa or levodopa/carbidopa combinations and may be potential side-effects with 'Sinemet CR' are listed below:Dopamine Dysregulation Syndrome (DDS) is an addictive disorder seen in some patients treated with carbidopa/ levodopa. The dose needs to be titrated further depending on clinical response, as indicated below under 'Titration'. (For patients receiving monamine oxidase inhibitors, see 4.3 'Contraindications').Anticholinergics may affect the absorption and thus the patient's response.Studies demonstrate a decrease in the bioavailability of carbidopa and/or levodopa when it is ingested with ferrous sulphate or ferrous gluconate.Dopamine D2 receptor antagonists (e.g. minoxidil moexipril hcl moexipril-hydrochlorothiazide NADOLOL-BENDROFLUMETHIAZIDE ... SINEMET SINEMET CR STALEVO TASMAR tolcapone trihexyphenidyl hcl XADAGO ANTIPSYCHOTICS/ ANTIMANIC AGENTS ... afeditab cr amlodipine besylate CALAN CALAN SR CORLANOR CARDIZEM CARDIZEM LA cartia xt diltiazem cd DILT-XR

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