These guidelines suggested that patients taking irbesartan 150 mg once daily be treated with either valsartan 80 mg or losartan 50 mg once daily and that patients taking irbesartan 300 mg once daily be treated with either valsartan 160 mg or losartan 100 mg once daily. The hypothesis of this study was that valsartan 80 mg or losartan 50 mg once daily provided BP control similar to that provided by irbesartan 150 mg once daily and that valsartan 160 mg and losartan 100 mg once daily provided BP control similar to that provided by irbesartan 300 mg once daily. American Heart Association website. Our findings may not be reproducible to all populations. Thus, 530 patients completed the 8-week, double-blind period. We did not have the ability to standardize the dosing of any additional antihypertensive agents, which may or may not have caused additional changes in BP measurements or in serum creatinine or serum potassium levels. 12. 5. Our findings were limited by the fact that this was a retrospective chart review. Department of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CODepartment of Family Medicine , School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CODepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, COHealth Economics & Outcomes Research, Daiichi Sankyo Inc., Parsippany, NJDepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CODepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CODepartment of Family Medicine , School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CODepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, COHealth Economics & Outcomes Research, Daiichi Sankyo Inc., Parsippany, NJDepartment of Clinical Pharmacy, University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, COUse the link below to share a full-text version of this article with your friends and colleagues. Additionally, it was expected that these switches did not cause significant changes in serum potassium or serum creatinine levels. Cozaar (losartan) and Avapro (irbesartan) are angiotensin receptor blockers (ARBs) used to treat hypertension.
We did not assess dosing of ARB therapy, which could have influenced BP changes and BP goal maintenance. Despite being at goal BP prior to the index date, 75 (19.5%) patients in this switch cohort were taking another ARB (losartan, irbesartan, or valsartan) in combination with another antihypertensive agent from a different drug class, as combination therapy.

Such drugs may also cause an allergic reaction that makes the face, lips and throat swell. ARBs may also have slightly less risk of causing angioedema. Due to the nature of EHR data, many patients did not have the exact ARB dose documented. The following outcomes were determined for each cohort: (1) mean systolic and diastolic BP values after the BP control index date, (2) changes in BP values after the BP control index date, and (3) percentage of patients maintaining BP values <140/90 mm Hg after the BP control index date.
Pfeffer MA, Swedberg K, Granger CB, et al; CHARM Investigators and Committees. The clinical impact of small differences in BP has been widely debated. "oh I'm going to die kind of feelings". losartan 50 or Irbesartan 150 mg. which is a better choice . Hypertension. 7. It was my eating habits and lack of exercise. It was expected that this ARB switch had the potential to affect >600 patients at Dorn and its affiliated CBOCs. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. This makes it possible for practitioners to choose an ARB based on clinical trial data and cost-effectiveness.

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