Nursing mothers who are ultra-rapid metabolizers may also experience overdose symptoms such as extreme sleepiness, confusion, or shallow breathing. Updated

The exact mechanism for this interaction is not known, however it is believed that chlorpheniramine may inhibit the hepatic metabolism of phenytoin. Codeine has embryolethal and fetotoxic effects in rats. 0722-7184-01 Toxic psychosis, a possible class effect from overdose of sedating antihistamines, has been reported with accidental overdose of chlorpheniramine. Toxic psychosis, a possible class effect from overdose of sedating antihistamines, has been reported with accidental overdose of chlorpheniramine.Treatment of overdosage consists of discontinuation of CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE together with institution of appropriate therapy. Call your doctor for medical advice about side effects. CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE is contraindicated for post-operative pain management in all pediatric patients undergoing tonsillectomy and/or adenoidectomy When prescribing codeine-containing drugs, healthcare professionals should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of morphine overdose. Clinical efficacy and safety studies have not been conducted with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE. This rapid conversion results in higher than expected serum morphine levels. Caution should be exercised when codeine is administered to a nursing woman. If a codeine containing product is selected, the lowest dose should be prescribed for the shortest period of time to achieve the desired clinical effect. In severe overdosage, apnea, circulatory collapse, cardiac arrest, and death may occur.Codeine may cause miosis, even in total darkness. Peripheral toxicity includes hypertension, tachycardia, dysrhythmias, vasodilation, hyperpyrexia, mydriasis, urinary retention, and diminished gastrointestinal motility. Oxidative metabolism of chlorpheniramine is catalyzed by cytochrome P-450 2D6.Approximately 90% of the total dose of codeine is excreted through the kidneys, of which approximately 10% is unchanged codeine. Dosage Oral: Seasonal allergic rhinitis, chronic idiopathic urticaria: Children 2-5 years: 5 mg once daily .

The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rate, increased stools, sneezing, yawning, vomiting, and fever. Find here Chlorpheniramine Maleate suppliers, manufacturers, wholesalers, traders with Chlorpheniramine Maleate prices for buying. Avoid exposure to heat. January 20, 2017 Chlorpheniramine is widely distributed throughout the tissues of the body, including the central nervous system. Cardiovascular and renal effects include difficulty in micturition, headache, flushing, palpitation, cardiac arrhythmia, hypertension with subsequent hypotension and circulatory collapse. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind.Use of codeine, an opioid, may result in the following: Use of chlorpheniramine, an antihistamine, may result in: Adverse reactions listed below have been reported in the literature for codeine and chlorpheniramine and may be expected to occur with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE. Antihistamines may cause excitability, especially in children. Version: 8.03.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Its chemical structure is as follows:Phenylephrine hydrochloride is a mydriatic and a decongestant with the chemical name: (Dextromethorphan hydrobromide is an antitussive with the chemical name 3-Methoxy-17-methyl-9α, 13α, 14α - morphinan hydrobromide monohydrate. Prescribe and administer CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE with the same degree of caution appropriate to the use of other opioid drugs. CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE should be used with caution in patients with severe renal impairment.Pharmacokinetics of CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE has not been characterized in hepatic impairment subjects. Morphine and its M6 glucuronide conjugate are pharmacologically active. Give primary attention to re-establishment of adequate respiratory exchange through provision of a patent airway and the institution of assisted or controlled ventilation. Elderly: Peak plasma levels are increased; elimination half-life is slightly increased; specific dosing adjustments are not available . See full prescribing information for CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE. chlorpheniramine may cause blurred vision or impair your thinking or reactions. CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE is for adults 18 years and older. Select one or more newsletters to continue.

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