This website also contains material copyrighted by 3rd parties. Applies to the following strengths: 125 mcg; 250 mcg; 500 mcgCorrected QT interval (QTc) and CrCl must be determined prior to the first dose. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Serious adverse events potentially related to treatment were reported in 7 patients (2.9%) in the dofetilide-treated groups and in 2 patients (2.3%) in the placebo-treated group.
Dose 4 QTc: _____ msec Dose 5 QTc: _____ msec (should be used rather than QTc.)
Epub 2013 Apr 26.Helldén A, Odar-Cederlöf I, Nilsson G, Sjöviker S, Söderström A, Euler Mv, Ohlén G, Bergman U.BMJ Open. Clipboard, Search History, and several other advanced features are temporarily unavailable.
Andrade JG, Hawkins NM, Fordyce CB, Deyell MW, Er L, Djurdjev O, Macle L, Virani SA, Levin A.Can J Cardiol. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Tikosyn (Dofetilide) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. The dosing algorithm shown above should be used to determine the individualized dose of TIKOSYN. How should Dofetilide be taken?
Epub 2018 Apr 25.Pokorney SD, Yen DC, Campbell KB, Allen LaPointe NM, Sheng S, Thomas L, Bahnson TD, Daubert JP, Picini JP, Jackson KP, Thomas KL, Al-Khatib SM.Heart Rhythm. Epub 2004 May 25.Expert Opin Investig Drugs. Tables & Protocols Missed Dose . If initial dose 250 mcg q12hr, decrease to 125 mcg q12hr; If initial dose 125 mcg q12hr, decrease to 125 mcg qDay; Monitoring. The following medications are
2172597-overview If at any time during the study the QT or QTc had increased by >25% or exceeded 550 ms, dofetilide was discontinued. Select one or more newsletters to continue.
Children—Use and dose must be determined by your doctor. It comes as a capsule to take by mouth, with or without food. Therapy with TIKOSYN must be initiated (and, if necessary, re-initiated) in a setting that provides continuous electrocardiographic monitoring and in the presence of personnel trained in the management of serious ventricular arrhythmias.Patients should continue to be monitored in this way for a minimum of three days. 2010 12. CrCl must be calculated via the Cockcroft-Gault equation (using actual body weight).CrCl greater than 60 mL/min: 500 mcg orally twice a dayMild to moderate liver dysfunction: No adjustment recommended.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Significant - Monitor Closely. We comply with the HONcode standard for trustworthy health information -
Keep from freezing.Do not keep outdated medicine or medicine no longer needed.Ask your healthcare professional how you should dispose of any medicine you do not use.Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health.
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
Repeat cardioversions on therapy were not permitted. Individual plans may vary
Diseases & Conditions For oral dosage form (capsules): For abnormal heart rhythm: Adults—125 to 500 micrograms (mcg) two times a day. Must be hospitalized to initiate. COVID-19 is an emerging, rapidly evolving situation. Do not double doses.Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
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