It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of lamivudine / tenofovir may occur that usually Check with your health care professional if any of the following side effects In a controlled trial with lamivudine, tenofovir disoproxil fumarate (DF), and Elevated fasting cholesterol (greater than 240 mg/dL) and fasting triglycerides (greater than 750 mg/dL) have been reported in 19% and 1% of patients using lamivudine, tenofovir DF, and efavirenz, respectively.-Postmarketing reports: Hyperglycemia, lactic acidosis, redistribution/accumulation of body fat-Postmarketing reports: Lactic acidosis, hypokalemia, hypophosphatemia-Frequency not reported: Redistribution/accumulation of body fat (including central -Postmarketing reports: Urticaria, alopecia, pruritus-Very rare (less than 0.01%): Peripheral neuropathy/paresthesia-Frequency not reported: Increased weight, increased blood lipid levelsProximal renal tubulopathy (including Fanconi syndrome) sometimes leading to bone abnormalities (infrequently contributing to fractures) has been reported.Rhabdomyolysis, osteomalacia, muscular weakness, and myopathy have occurred as a result of proximal renal tubulopathy.-Postmarketing reports: Muscle weakness, elevated creatine phosphokinase, rhabdomyolysis-Uncommon (0.1% to 1%): Rhabdomyolysis, muscular weakness-Frequency not reported: Bone abnormalities (infrequently contributed to fractures)-Postmarketing reports: Rhabdomyolysis, osteomalacia (manifested as bone pain and infrequently contributed to fractures), muscular weakness, myopathy-Common (1% to 10%): Nausea, vomiting, abdominal pain/cramps, diarrhea-Very common (10% or more): Diarrhea, vomiting, nausea-Postmarketing reports: Pancreatitis, increased amylase, abdominal painIncreased serum amylase (greater than 175 units/L) has been reported in 9% of patients using lamivudine, tenofovir DF, and efavirenz.Pancreatitis (some cases fatal) has been reported in antiretroviral nucleoside-experienced pediatric patients using lamivudine alone or in combination with other antiretroviral agents.-Postmarketing reports: Hepatic steatosis, posttreatment exacerbation of hepatitis B-Rare (0.01% to 0.1%): Hepatic steatosis, hepatitis-Frequency not reported: Acute exacerbation of hepatitis-Postmarketing reports: Hepatic steatosis, hepatitis, increased liver enzymes (most commonly AST, ALT, GGT)Elevated AST (males: greater than 180 units/L; females: greater than 170 units/L) and ALT (males: greater than 215 units/L; females: greater than 170 units/L) have been reported in 5% and 4% patients using lamivudine, tenofovir DF, and efavirenz, respectively.Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs.Severe acute exacerbations of hepatitis B have been reported in patients coinfected with HIV-1 and hepatitis B virus after discontinuation of lamivudine or tenofovir DF.Hepatic decompensation (some fatal) has been reported in patients coinfected with HIV-1 and hepatitis C receiving combination antiretroviral therapy for HIV-1 and interferon alfa with or without Decreased neutrophils (less than 750/mm3) has been reported in 3% of patients using lamivudine, tenofovir DF, and efavirenz.-Very rare (less than 0.01%): Pure red cell aplasia-Postmarketing reports: Anemia (including pure red cell aplasia and severe anemias progressing on therapy)Proximal renal tubulopathy generally resolved or improved after tenofovir DF was stopped; however, decreased CrCl did not completely resolve in some patients after stopping tenofovir DF. The combination is a type of antiretroviral therapy. ([2018, May 30]):7. 300 mg Tenofovir Disoproxil Fumarate NEW FIXED aspen 300 mg Lamivudine 50 mg Dolutegravir Healthcare. Clin Pharmacokinet 45 (2006): 1115-248. ([2018, May 22):2. 3. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - J Antimicrob Chemother 62 (2008): 879-8813. "Product Information. Anderson PL "Pharmacologic perspectives for once-daily antiretroviral therapy." Lancet 370 (2007): 89-936. As of 2019 , it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative. Putting them into clinical context. patient with proteinuria and progressive renal dysfunction warranted.Along with its effects... Jaffe HW `` Pre-exposure prophylaxis for HIV infection effects at https: //aidsinfo.nih.gov/contentfiles/lvguidelines/pediatricguidelines.pdf ''. 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