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Each scored white tablet contains 100 mg allopurinol and the Clinical Drug Interactions Source: Medscape from WebMDDisclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider.

For patients with a creatinine clearance between 10 and 20 mL/min, a dose of 200 mg per day is recommended. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Hydroxyurea may cause severe bone marrow suppression/myelosuppression (e.g., leukopenia, anemia, neutropenia, and thrombocytopenia).

Allopurinol reduces both the serum and urinary uric acid levels by inhibiting the formation of uric acid. The increased xanthine and hypoxanthine in the urine have not been accompanied by problems of nephrolithiasis. It is a xanthine oxidase inhibitor which is administered orally. Patients should be treated with the lowest effective dose, in order to minimize possible side effects. Renal function should be monitored in patients on thiazide diuretics and allopurinol (see An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs. Evaluate hematologic status before and during treatment (weekly for cancer and every 2 weeks for sickle cell disease). As a result, the concomitant administration of uricosuric agents decreases the inhibition of xanthine oxidase by oxypurinol and increases the urinary excretion of uric acid.Reports that the concomitant administration of allopurinol and thiazide diuretics contributed to increased allopurinol toxicity were reviewed; a causal mechanism or cause-and-effect relationship was not found. The gout was incredibly painful, so I'm quite happy to take another pill which I know will prevent that pain. Tell your Hydroxyurea (Hydrea) is used alone or with other medications or radiation therapy to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells) and certain types of head and neck cancer (including cancer of … There are isolated case reports of xanthine crystalluria in patients who were treated with oral allopurinol.The action of oral allopurinol differs from that of uricosuric agents, which lower the serum uric acid level by increasing urinary excretion of uric acid. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Do not use this product if particulate matter or discoloration is present.The following table lists drugs that are physically incompatible in solution with Aloprim (allopurinol sodium) for Injection.Aloprim (allopurinol sodium) for Injection, 30 mL flint glass vials with rubber stoppers each containing allopurinol sodium equivalent to 500 mg of allopurinol (white lyophilized powder).The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. All rights reserved. There has been no clinical experience in the management of a patient who has taken massive amounts of allopurinol.Both allopurinol and oxypurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of Aloprim (allopurinol sodium) for Injection is unknown.The dosage of Aloprim (allopurinol sodium) for Injection to lower serum uric acid to normal or near-normal varies with the severity of the disease. and p.o. Since the effect of allopurinol on the nursing infant is unknown, caution should be exercised when allopurinol is administered to a nursing woman.Clinical data are available on approximately 200 pediatric patients treated with Aloprim (allopurinol sodium) for Injection. This oxidation, which is catalyzed by xanthine oxidase, inactivates mercaptopurine. The suppression has occurred from as early as 6 weeks to as long as 6 years after the initiation of allopurinol therapy.The correct dosage and schedule for maintaining the serum uric acid within the normal range is best determined by using the serum uric acid as an index.In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy (see Allopurinol and its primary active metabolite, oxypurinol, are eliminated by the kidneys; therefore, changes in renal function have a profound effect on dosage. You may also report side effects at https://www.fda.gov/medwatch. Combination may increase risk of myelosuppression.Never use this combination of drugs because of high risk for dangerous interactionPotential for serious interaction; regular monitoring by your doctor required or alternate medication may be neededPotential for significant interaction (monitoring by your doctor is likely required)Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.

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