Similarly, ketoconazole may modify the pharmacokinetics of other substances that share this metabolic pathway. Tests that your doctor may do include:The cost of these tests will depend on your insurance.Ketoconazole can make your skin more sensitive to the sun. It’s available as an oral tablet, topical cream, topical foam, shampoo, and topical gel. This drug is only given when other treatments haven’t worked or caused too many side effects.Ketoconazole belongs to a class of drugs called antifungals. Concomitant administration of Ketoconazole Tablets with oral triazolam, oral midazolam or alprazolam is contraindicated. These drugs should be used with caution when coadministered with Ketoconazole Tablets. Uses. Ketoconazole is a potent CYP3A4 inhibitor and a P-glycoprotein inhibitor. All rights reserved. Select one or more newsletters to continue. Patients who must take Ketoconazole Tablets concomitantly with potent inhibitors of CYP3A4 should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of ketoconazole, and the Ketoconazole Tablets dose should be decreased as deemed necessary. Your doctor may do tests during your treatment with this drug. Testosterone levels are impaired with doses of 800 mg per day and abolished by 1600 mg per day. Ketoconazole tablets are indicated for the treatment of fungal infections as well as some yeast and dermatophyte (ringworm) infections. Ketoconazole can cause elevated plasma concentrations of these drugs which may prolong the QT interval, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.Ketoconazole Tablets decrease adrenal corticosteroid secretion at doses of 400 mg and higher.

Serious side effects and their symptoms can include the following:Ketoconazole oral tablet can interact with other medications, vitamins, or herbs you may be taking. If you drink alcohol, talk to your doctor.Talk to your doctor if you’re pregnant or planning to become pregnant. Talk to your doctor about other drug options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Taking certain drugs with ketoconazole raises your risk of side effects.Ketoconazole tablets can cause a severe allergic reaction.

The safety and effectiveness of ketoconazole have not been established in these settings and the use of ketoconazole for these indications is not approved by FDA. If they’re more severe or don’t go away, talk to your doctor or pharmacist.Call your doctor right away if you have serious side effects. During the course of treatment, serum ALT should be monitored weekly for the duration of treatment. In vitro studies have shown that CYP3A4 is the major enzyme involved in the metabolism of ketoconazole. Patients should be advised against alcohol consumption while on treatment. Gastrointestinal signs of anorexia, vomiting, and/or diarrhea and weight loss are the most common adverse effects seen with ketoconazole therapy and are more prevalent in cats. However, sometimes it needs to be taken for several months. Serious hepatotoxicity was reported both by patients receiving high doses for short treatment durations and by patients receiving low doses for long durations.The hepatic injury has usually, but not always, been reversible upon discontinuation of ketoconazole treatment. Ketoconazole Tablets have not been studied in children under 2 years of age.Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP.Using Ketoconazole Tablets with certain other medicines may affect each other. The major route of excretion is through the bile into the intestinal tract with about 57% being excreted in the feces.In patients with hepatic or renal impairment, the overall pharmacokinetics of ketoconazole was not significantly different when compared with healthy subjects.Limited pharmacokinetic data are available on the use of Ketoconazole Tablets in the pediatric population.Measurable ketoconazole plasma concentrations have been observed in pre-term infants (single or daily doses of 3 to 10 mg/kg) and in pediatric patients 5 months of age and older (daily doses of 3 to 13 mg/kg) when the drug was administered as a suspension, tablet or crushed tablet. This drug should be used only if the potential benefit justifies the potential risk to the fetus.All possible dosages and drug forms may not be included here. When appropriate, plasma concentrations should be measured.

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