Chronic kidney disease may not become apparent until y… The dose in these patients should not exceed 40 mg/day.Dosing recommendation for patients taking LATUDA concomitantly with potential CYP3A4 inducers: LATUDA should not be used in combination with a strong CYP3A4 inducer (e.g., rifampin). Applies to: Neuroleptic Malignant SyndromeThe central dopaminergic blocking effects of neuroleptic agents may precipitate or aggravate a potentially fatal symptom complex known as neuroleptic malignant syndrome (NMS). Hyperprolactinemia may suppress hypothalamic gonadotrophin releasing hormone (GnRH), resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Chronic administration of neuroleptic drugs has been associated with mammary tumorigenesis in rodent studies but not in human clinical or epidemiologic studies. Neuroleptic agents should not be given to patients with active NMS and should be immediately discontinued if currently being administered in such patients. This risk is greatest in patients with a history of seizures or with conditions that lower the seizure threshold. Applies to: HyperlipidemiaAtypical antipsychotic drugs have been associated with undesirable alterations in lipid levels. This eMedTV segment lists other precautions and warnings with Latuda, such as those relating to drug interactions and the safety of taking this antipsychotic medication during pregnancy. NMS is observed most frequently when high-potency agents like haloperidol are administered intramuscularly, but may occur with any neuroleptic agent given for any length of time. Major Potential Hazard, High plausibility. In patients with preexisting drug-induced TD, initiating or increasing the dosage of neuroleptic therapy may temporarily mask the symptoms of TD but could eventually worsen the condition. Applies to: Renal DysfunctionTherapy with some atypical antipsychotic agents should be administered cautiously in patients with renal impairment and the dosage should be reduced accordingly. Applies to: ObesityWeight gain has been observed with atypical antipsychotic use. Applies to: DysphagiaEsophageal dysmotility and aspiration have been associated with the use of antipsychotic drugs.

The effectiveness of LATUDA for longer-term use, that is, for more than 6 weeks, has not been established in controlled studies. In controlled trials, treatment with some atypical antipsychotic drugs was also associated with an increased risk of cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, in elderly patients with dementia- related psychosis. We comply with the HONcode standard for trustworthy health information -

Applies to: Seizures, Head Injury, AlcoholismAntipsychotic and neuroleptic drugs can lower the seizure threshold and trigger seizures in a dose-dependent manner. However, patients may infrequently develop symptoms after relatively brief treatment periods at low dosages. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. Additional signs may include elevated creatine phosphokinase, myoglobinuria, and acute renal failure. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds; however, the clinical significance of elevated serum prolactin levels is unknown for most patients. Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Caution is also advised in patients with preexisting hyperprolactinemia. Applies to: NeutropeniaCases of leukopenia, neutropenia, and agranulocytosis have been reported with the use of atypical antipsychotic agents. If you or someone you love struggles with bipolar depression, there are treatment options available to you. A causal relationship with antipsychotic use has not been established. The clinical significance of this observation with respect to long-term neuroleptic therapy is unknown. Patients with preexisting low white blood cell count may be at increased risk. Based on in vitro data, approximately one-third of human breast cancers are thought to be prolactin-dependent. While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile.

Neuroleptic agents may precipitate symptoms of tardive dyskinesia (TD), a syndrome consisting of rhythmic involuntary movements variously involving the tongue, face, mouth, lips, jaw, and/or trunk and extremities, following chronic use of at least several months but often years.

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