Along with its needed effects, a medicine may cause some unwanted effects.

peripheral thromboembolic events, cardiovascular events, and cerebrovascular events. In doing so, we compare LETROZOLE with other drugs that cause OCULAR ICTERUS, to help you evaluate whether or not LETROZOLE causes OCULAR ICTERUS. of postmenopausal women with hormone receptor and node positive breast cancer (FACE, NCT00248170), the median

Drug information provided by: IBM Micromedex.

This is not a complete list of side effects and others may occur. For many people, side effects improve within the first few months of starting the treatment. They may be able to offer ways of improving your symptoms. The Side Effects of Letrozole & Cholesterol: The side effects of Letrozole can include those surrounding cholesterol, and this is an issue some steroid users tend to have a hard time with. found this review helpful.Reviewer: Connie, 55-64 Female on Treatment for 1 to 6 months (Patient) 23 Because these reactions are reported Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. “Certainly, the side effects we see with tamoxifen are much less profound than they used to be because of the lower doses now used.” Years ago, many breast cancer patients were prescribed doses of 150 mg or more, he noted. Peripheral thromboembolic events included
side effect profiles of the two drugs.Adverse reactions were analyzed irrespective of whether a symptom was present or absent at baseline. The overwhelming data shows AI’s like Letrozole have very little affect on cholesterol, and if … Feel Like Throwing Up 5.

This side effect is also the reason why this profile has emphasized the control of Estrogen levels rather than the total elimination of them. Condition: Hormone Receptor Positive Breast Cancer endometrial hyperplasia/cancer (0.3% vs 2.9%), and endometrial proliferation disorders (0.3% vs 1.8%) (Femara vs Side Effects. tamoxifen respectively).At a median follow-up of 96 months, a higher incidence of events was seen for Femara (14.7%) than for tamoxifen

The incidence of adverse reactions was similar for Femara and tamoxifen.

You may report side effects to FDA at 1-800-FDA-1088. observed in practice.In study, BIG 1-98, the median treatment duration of adjuvant treatment was 60 months and the median duration of follow-up for
Other drugs may interact with Femara.

arterial thrombosis, memory impairment, irritability, nervousness, urticaria, increased urinary frequency, leukopenia, stomatitis

Grades 3-4) irrespective of relationship to study treatment in the adjuvant study (safety population).The following adverse reactions were also identified in less than 5% of the 2049 patients treated with letrozole and not included in There was also less vaginal patient’s metastatic breast cancer, the effects of estrogen deprivation, or intercurrent illness.Adverse reactions that were reported in at least 5% of the patients treated with Femara 0.5 mg, Femara 2.5 mg, megestrol acetate, or Bone fracture 2. breast pain 3. chest pain 4. chills, fever, or flu-like symptoms 5. mental depression 6. swelling of the feet or lower legs observed for Femara (10.4%) compared to placebo (5.8%), as also a higher rate of osteoporosis (Femara 12.2% vs placebo 6.4%).Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of new Our Femara (letrozole) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.



people in the adjuvant setting comparing the effect on lumbar spine (L2-L4) BMD of adjuvant treatment with letrozole to that fractures (10.1% vs 7.1%), myocardial infarctions (1.0% vs 0.5%), and arthralgia (25.2% vs 20.4%) (Femara vs thrombotic or hemorrhagic strokes and development of hemiparesis.Study discontinuations in the megestrol acetate comparison study (AR/BC2) for adverse reactions other than progression of tumor Femara is a potent hormone drug and only your physician can assess if it can be of benefit to you and in what doses. The recommended dose of Femara is one 2.5 mg tablet administered once a day, without regard to meals. These side effects may go away during treatment as your body adjusts to the medicine. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. High Cholesterol 8. See below for a comprehensive list of adverse effects.

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