Included studies used heterogeneous sildenafil doses (range 0.5 to 3.0 mg/kg every 6 hours) and variable loading doses. However, large-scale randomised trials comparing sildenafil versus active controls (other pulmonary vasodilators) and providing follow-up for survivors are needed … 2007 Jul 18;(3):CD005494. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Wiley 2019 Nov 5;9(11):e032122. doi: 10.1002/14651858.CD005494.pub4. 2017 Jan 5;1(1):CD000399. Unable to load your delegates due to an error doi: 10.1002/14651858.CD005494.pub2.Cochrane Database Syst Rev. Risk of bias graph: review authors' judgements about each risk of bias item presented… Risk of bias summary: review authors' judgements about each risk of bias item for… Comparison 1 Sildenafil versus placebo, Outcome 1 Pulmonary arterial pressure. 2006 Apr;117(4):1077-83. doi: 10.1542/peds.2005-0523.Khorana M, Yookaseam T, Layangool T, Kanjanapattanakul W, Paradeevisut H.Goldman AP, Tasker RC, Haworth SG, Sigston PE, Macrae DJ.Cruz-Blanquel A, Espinosa-Oropeza A, Romo-Hernández G, Carrillo-Alarcón L, Ponce-Monter H, Ortiz MI.Pediatr Pulmonol. Clipboard, Search History, and several other advanced features are temporarily unavailable. Comparison 2 Sildenafil versus active control, Outcome 1 All‐cause mortality. 2016 Aug 18;(8):CD010531. doi: 10.1136/bmjopen-2019-032122. Clipboard, Search History, and several other advanced features are temporarily unavailable. doi: 10.1136/bmjopen-2019-032122. eCollection 2020.Paediatr Drugs. Pediatrics. Free PMC article

2003 Dec;36(6):529-35. doi: 10.1002/ppul.10389.Martinho S, Adão R, Leite-Moreira AF, Brás-Silva C.Front Pediatr. Comparison 1 Sildenafil versus placebo, Outcome 7 A‐a DO Comparison 1 Sildenafil versus placebo, Outcome 8 Mean airway pressure. eCollection 2020.Pandya S, Baser O, Wan GJ, Lovelace B, Potenziano J, Pham AT, Huang X, Wang L.J Health Econ Outcomes Res. However, large-scale randomised trials comparing sildenafil versus active controls (other pulmonary vasodilators) and providing follow-up for survivors are needed to … doi: 10.1002/14651858.CD010531.pub2.Bruschettini M, O'Donnell CP, Davis PG, Morley CJ, Moja L, Calevo MG.Cochrane Database Syst Rev. Cochrane Database Syst Rev. Comparison 3 Sildenafil plus iNO versus placebo plus iNO, Outcome 4 Duration of… Comparison 3 Sildenafil plus iNO versus placebo plus iNO, Outcome 5 Retinopathy of… doi: 10.1002/14651858.CD004953.pub4.Martinho S, Adão R, Leite-Moreira AF, Brás-Silva C.Front Pediatr.
Unable to load your delegates due to an error Comparison 1 Sildenafil versus placebo, Outcome 4 All‐cause mortality. eCollection 2019.O'Dea M, Sweetman D, Bonifacio SL, El-Dib M, Austin T, Molloy EJ.Front Pediatr. 2011 Aug 10;(8):CD005494. Comparison 2 Sildenafil versus active control, Outcome 2 Time to adequate response (days). Epub 2019 Nov 18.Cochius-den Otter S, Schaible T, Greenough A, van Heijst A, Patel N, Allegaert K, van Rosmalen J, Tibboel D; CDH EURO Consortium.BMJ Open. 2020 May 15;8:239. doi: 10.3389/fped.2020.00239. 2019 Nov 5;9(11):e032122. Comparison 2 Sildenafil versus active control, Outcome 3 Duration of ventilation (days). Comparison 1 Sildenafil versus placebo, Outcome 6 Change in oxygenation index.

2020 Feb;76(2):219-227. doi: 10.1007/s00228-019-02767-1. Unable to load your collection due to an error Please enable it to take advantage of the complete set of features! Authors' conclusions: Sildenafil used for treatment of pulmonary hypertension has potential for reducing mortality and improving oxygenation in neonates, especially in resource-limited settings where iNO is not available.

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