Caffeine clearance is increased by more than 50% in smokersOther medicines may also be affected such as: verapamil, propranolol, Clin Pharmacokinet. Doing so can intensify both desirable and … Cigarette smoking produces polycyclic aromatic … To purchase short term access, please sign in to your Oxford Academic account above. Clipboard, Search History, and several other advanced features are temporarily unavailable. 0 Then Propanolol (Inderal) 14. Please enable it to take advantage of the complete set of features! Nicotine replacement therapy does not influence CYP1A2 activity.Genetic polymorphisms of the CYP1A2 gene contribute to extensive inter-individual variability in drug metabolismCYP1A2 activity is significantly higher in heavy smokers (more than 20 cigarettes/day) than in nonsmokers.This enzyme induction is rapidly reversed when patients abruptly stop smoking, with a new steady state of CYP1A2 activity reached after approximately one week.Cigarette smoking induces the metabolism of clozapine and olanzapine,Irrespective of smoking status, the mean oral bioavailability of clozapine is 27–47% and clozapine plasma concentrations have more than a 45-fold variability amongst individuals during chronic treatment.Non-smokers are at higher risk of adverse effects if treated with standard doses, suggesting that there is an interaction between smoking, olanzapine and clozapine.Clearance of clozapine has been shown to decrease when smoking is ceased, with a mean increase of 72% in plasma clozapine concentrations.As fluvoxamine is metabolised by CYP1A2, smokers might require higher doses than those recommended from clinical trial data.Smokers might require higher than normal doses of the tricyclic antidepressant imipramine. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. GBP £29.00 •Chemicals in tobacco smoke (polycyclic aromatic hydrocarbons) accelerate the metabolism of clozapine and olanzapine (by inducing the cytochrome enzyme CYP1A2) lowering drug blood levels. End if Health professionals also need to stay up to date with the latest evidence as it emerges.

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