If statin therapy cannot be successfully reintroduced, other classes of lipid-lowering drugs should be considered. 2010 Feb 15;172(7):544-5. A 68-year-old man was referred with progressive dysphagia. ScienceDirect ® is a registered trademark of Elsevier B.V.© 2019 Société française de rhumatologie. Ugeskr Laeger. Severe SAMSs with major weakness and marked CK elevation should suggest the rare eventuality of necrotizing autoimmune myopathy and prompt an anti-HMGCR antibody assay and muscle biopsy to ensure that immunosuppressant therapy is started rapidly if needed.We use cookies to help provide and enhance our service and tailor content and ads. As an increasing number of patients are being treated with lipid-lowering drugs, it is important to recall that myopathy is a dangerous side-effect which may have either quick or delayed onset, and that dysphagia can be the initial symptom. HMG-CoA reductase inhibition in muscles by statins exerts pleiotropic effects that can affect energy metabolism, induce mitochondrial dysfunction, modify lipid oxidation, promote apoptosis and cell membrane lysis, alter muscle protein synthesis, or trigger an autoimmune process. 2006 May-Jun;22(3):222-4. doi: 10.1097/01.iop.0000217573.90522.48.Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, Vladutiu GD, England JD; Scripps Mercy Clinical Research Center.Ann Intern Med. The dysphagia was a late-onset side-effect to the treatment with lipid-lowering drugs. Otherwise, the risks should be weighed against the benefits before reinitiating statin therapy, and a different statin or lower dosage should be used. Onset is usually within 1 month after statin initiation or dosage intensification, and the symptoms can be expected to resolve within a few weeks after treatment discontinuation.

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Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. Because of this there are moves toward their use in primary prevention of atherosclerosis . During the course, the patient developed muscle fatigue and additional signs of myopathy such as high levels of creatine kinase. Please enable it to take advantage of the complete set of features! 2010 Apr 19;172(16):1235; author reply 1235.Ertas FS, Ertaş NM, Gulec S, Atmaca Y, Tanju S, Sener C, Erol C.Ophthalmic Plast Reconstr Surg. doi: 10.7326/0003-4819-137-7-200210010-00004.South Med J. Statins lower cholesterol levels, which can decrease the risk of cardiovascular and cerebrovascular disorders. The most common events associated with statin intolerance are myopathy and increased risk of developing type 2 diabetes … Published by Elsevier Masson SAS. 1.

Myalgia with CK elevation is the most common presentation. The study is created by eHealthMe based on reports of 644 people who take Lipitor and Acyclovir from the Food and Drug Administration (FDA), and is updated regularly. Indications. The mechanism of muscle injury combines statin accumulation within muscles, which varies with the type and dosage of the drug; muscle fragility; abnormalities in statin transport or liver metabolism; drug-drug interactions; and genetic susceptibility. The dysphagia was a late-onset side-effect to the treatment with lipid-lowering drugs. 2002 Oct 1;137(7):I45. Statin side effects: Weigh the benefits and risks. By Mayo Clinic Staff. Statins in rheumatology 1.1. COVID-19 is an emerging, rapidly evolving situation. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors.

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