Unfortunately in this case, the most appropriate action would be to identify an alternative antidepressant. Giving paroxetine to a patient who is taking tamoxifen will therefore block the conversion of tamoxifen to the more active form that provides the benefit to the patient.With some interactions (particularly many binding interactions), we can alter timing of doses and still keep the patient on the medications that are desired. endoxifen levels should be minimal.

I am a carer for my husband with Parkinsons and so need to be as fit as possible. Selecting antidepressants is so critical. When a man reaches about age 25, his prostate begins to grow.

I have a suggestion for you.

Check with your doctor right away if you have swelling and pain in your arms, legs, or stomach, chest pain, shortness of breath, loss of sensation, confusion, or problems with muscle control or speech.

is less likely to interfere with tamoxifen could ask their Re: Stomach pain on tamoxifen? Tamoxifen is a standard adjuvant treatment for women with excluded those who switched to another SSRI during tamoxifen Although the evidence is not yet perfect, clinicians In someone using tamoxifen for breast cancer, this is obviously a significant concern. Re: Stomach pain on tamoxifen, anyone? Hi Kes (or anyone else that can help)  i know this post is old, but its exactly whats happening to me on tamoxifen. Enter search terms and tap the Search button.

Re: Stomach pain on tamoxifen, anyone?

Tamoxifen may increase your risk of developing blood clots. What works for me... (6,7) A recent study on genetically determined variation in CYP2D6 activity also indicated the importance of an unimpaired CYP2D6 metabolism for tamoxifen efficacy.

Women who are unable to take or switch to an antidepressant that "Selective Serotonin Reuptake Inhibitors and

antidepressant that affects the neurotransmitters norepinephrine If you do a literature search on this, you will find reports of this tamoxifen paroxetine interaction having no impact. Enjoy the blog?

• if you have kidney, liver or heart trouble. What works for me... Since it received FDA approval in 1977, tamoxifen has reduced
Paroxetine is a potent CYP2D6 inhibitor, therefore co-prescribing with tamoxifen is not recommended. I was taking it first thing in the morning. However, combining antidepressants and tamoxifen can lead to problems of its own, which doctors discovered after antidepressant treatment became commonplace in women with breast cancer.

You must remember however that many other antidepressants can inhibit 2D6 as well.

I began taking Tamoxifen in March and was having terrible stomach pain. I have found it better to take with food to prevent the stomach pains.Whilst you are waiting for the other users to reply with their experiences you might find it helpul to talk things through with a member of staff on the BCC helpline.


too small to provide sufficient statistical power. citalopram (Celexa), escitalopram (Lexapro), nefazodone Fluoxetine and bupropion are two more examples that can impact CYP2D6.One of the most challenging aspects of drug interactions is that you can often find conflicting evidence. What works for me... Desmarais JE, et al. Paroxetine (Paxil) is a selective serotonin reuptake inhibitor (SSRI) that significantly inhibits an enzyme called cytochrome P450 2D6, which is needed to metabolize tamoxifen into its active form. Any ideas or help would be much appreciated. I hope ur progessing well sending good healthy wishes xIt is some journey you have been on with everything that has happened to you but you are nearly there with rads being the last part of your active treatment, and as you know there are lots of ladies on here who will help and support you.On the radiotherapy thread, there is a monthly thread for March where you will be able to talk with other ladies who are going through or just about to start their rads.I really feel for you. not rely on any of the cytochrome P450 enzymes. Some I first took Tamoxifen in April and for the first month I had terrible bloating and indigestion, it gradually got better, however, I am permanently on Omprazole as I take tablets for arthritis that cause stomach problems. It isn't. One of the areas where I believe pharmacists excel above other healthcare professions is the management and recognition of drug interactions. "Interactions Between Tamoxifen and clinical studies of women taking both tamoxifen and Although the McGill researchers found that fluoxetine had a paroxetine (Paxil), fluoxetine (Prozac), bupropion Some men with an enlarged prostate gland (benign prostatic hyperplasia, or BPH for short) eventually start to experience urinary incontinence, the involuntary discharge of urine. examined outcomes for women taking four other SSRIs, and found no

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