Use non-hormonal contraception when you stop taking Tri-Lo-Sprintec.What should I tell my healthcare provider before taking Tri-Lo-Sprintec?Tell your healthcare provider about all the medicines you take,What are the possible serious side effects of Tri-Lo-Sprintec?Like pregnancy, Tri-Lo-Sprintec may cause serious side effects, including blood clots in your lungs, heart attack, or a stroke that may lead to death. 100.0 % 0.0 % Generic vs. * Approximation only. Take with food if it causes an upset stomach. Oral dosage (triphasic product containing 25 mcg of ethinyl estradiol, e.g, Ortho Tri-Cyclen Lo, Tri-Lo-Estarylla, Tri-Lo Marzia, Trinessa Lo, Tri-Lo-Sprintec) Adult and Adolescent females The dosage regimen is 1 tablet PO once daily in the order indicated in the pack for 21 days, followed by 1 inactive tablet PO once daily for 7 days. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Subjects were followed for up to 13 28-day cycles.The following additional adverse drug reactions have been reported from worldwide postmarketing experience with norgestimate/ethinyl estradiol. Some women may miss a period. After you have taken the last inactive tablet in the pack or gone 7 days without taking an active tablet, start a new pack the next day whether or not you have your period. TRI-LO-SPRINTEC- norgestimate and ethinyl estradiol kit Do not use COCs during pregnancy to treat threatened or habitual abortion.Advise the nursing mother to use other forms of contraception, when possible, until she has weaned her child. This is less likely to occur once breastfeeding is well-established; however, it can occur at any time in some women. Each one works well for some people and not well for others. When you begin on a certain day it is important that you follow that schedule, even if you miss a dose. NGM is rapidly and completely metabolized by first pass (intestinal and/or hepatic) mechanisms to norelgestromin (NGMN) and norgestrel (NG), which are the major active metabolites of NGM.Mean pharmacokinetic parameters for NGMN, NG and EE during three cycles of administration of Tri-Lo-Sprintec are summarized in Table 3.Peak serum concentrations of NGMN and EE were generally reached by 2 hours after administration of Tri-Lo-Sprintec. A small amount passes into breast milk and may have undesirable effects on a nursing Some products that may interact with this drug include: aromatase inhibitors (such as Tell your doctor when you start any new drug, and discuss if you should use additional reliable birth control. A past history of COC-related cholestasis predicts an increased risk with subsequent COC use. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body.This medicine has specific patient instructions on what to do if you miss a dose. In case of severe vomiting or diarrhea, absorption may not be complete and additional contraceptive measures should be taken. Women with a history of pregnancy-related cholestasis may be at an increased risk for COC related cholestasis.Carefully monitor prediabetic and diabetic women who take Tri-Lo-Sprintec. You should have regular complete physical exams which include laboratory and medical tests (such as Refer to the product package information for advice on missed doses. 3.45 % If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different contraceptive product.In the clinical trial of norgestimate and ethinyl estradiol, the frequency and duration of unscheduled bleeding and/or spotting was assessed in 1,673 women (11,015 evaluable cycles). CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase plasma hormone concentrations.Significant changes (increase or decrease) in the plasma concentrations of estrogen and/or progestin have been noted in some cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir])/HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine] or increase [e.g., etravirine]).The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.Do not co-administer Tri-Lo-Sprintec with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT elevations There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy.

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