The Sodium Correction Rate for Hyponatremia Calculates recommended fluid type, rate and volume to correct hyponatremia slowly (or more rapidly if seizing).

To ascertain possible determinants of carbamazepine (CBZ)– and oxcarbazepine (OXC)–induced hyponatremia in a large cohort of people with epilepsy.We collected data on serum sodium levels in people with epilepsy who were attending a tertiary epilepsy center while on treatment with CBZ or OXC. JWS has received research funding from Eisai, GSK, and UCB, and personal fees from Eisai, UCB Lundbeck, and Teva, outside the submitted work. Regular ascertainment of sodium levels in those taking either drug is recommended and results should be acted on.The antiepileptic drugs (AEDs) carbamazepine (CBZ) and its keto‐analogue oxcarbazepine (OXC) are among the drugs of choice for the treatment of focal epilepsy. If you have questions about side effects, call your doctor. Both were associated with hyponatremia more often than CBZ (16%). In a multivariate logistic regression analysis, age over 40 increased the odds of hyponatremia by a factor of 2.5 in the CBZ group and 2.2 in the OXC group.The hyponatremia frequency in different age categories for CBZ and OXC users is shown in Figure Monotherapy was associated with a lower risk of hyponatremia than polytherapy. Eyesight problems include not being able to see to the side when looking straight ahead and only being able to see straight ahead. Hyponatremia can be classified according to the volume status of the patient as hypovolemic, hypervolemic, or euvolemic. The underlying mechanisms are likely to be similar but seem more efficient when OXC is used. In the CBZ group, being female was a risk factor in the linear regression analysis, but with a very small effect size. Acute hyponatremia merits rapid correction to prevent brain herniation, but overtreatment of hyponatremia can lead to osmotic demyelination syndrome.

Call your doctor or get medical advice about side effects. However, many people have no side effects or only have minor side effects. taken, how much, and when it happened. Female patients on OXC were at a higher risk than male patients of hyponatremia. Among those who were symptomatic, 6% had CBZ or OXC levels above the therapeutic range (10 with CBZ levels ≥11, one with OXC level ≥35). We have seen a relatively high frequency of severe hyponatremia, especially in those treated with OXC. To confirm low blood sodium, your doctor will order blood tests and urine tests. He is a member of the editorial board of Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. The study was conducted at a single tertiary referral center, and it is likely that levels were estimated more frequently than in the primary or secondary levels of care.It is important for clinicians to be aware of the high prevalence of COIH and nonspecific symptoms. People taking this medicine (vigabatrin tablets) do not lose all of their eyesight but loss of eyesight can be very bad. Mild to moderate COIH may cause lethargy, cognitive slowness, headache, dizziness and nausea.

We thank Janic van Zijl, Marita Devile, Trusjen Punte, and Anja Sonsma, for helping with data collection.

All participants had previously provided written informed consent for data retrieval.We identified 1,732 people (94% Caucasian) who had used CBZ (n = 1,424) or OXC (n = 358); sodium levels were not measured or not recorded in 361 (21%). Hyponatremia is an important electrolyte abnormality with the potential for significant morbidity and mortality.

This, however, may reflect clinical practice in which some people, due to pressure of time and dislike of venipuncture, do not have samples taken for assay.

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