We encourage you to read the privacy policy of every website you visit.Click “Continue” to proceed or “Cancel” to return to NARCAN.com.Seek emergency medical assistance immediately after initial use, keeping the patient under continued surveillance.In neonates, opioid withdrawal may be life-threatening if not recognized and properly treated and may also include convulsions, excessive crying, and hyperactive reflexes. No pediatric studies were conducted for Narcan Nasal Spray.Absorption of naloxone hydrochloride following intranasal administration in pediatric patients may be erratic or delayed. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.You and your family members or caregivers should read the Instructions for Use that comes with Narcan Nasal Spray before using it. Signs and symptoms have included: body aches, fever, sweating, runny nose, sneezing, piloerection, yawning, weakness, shivering or trembling, nervousness, restlessness or irritability, diarrhea, nausea or vomiting, abdominal cramps, increased blood pressure, tachycardia.

Expanding the awareness and availability of this medication is a key part of the public health response to the opioid epidemic. Death, coma, and encephalopathy have been reported as sequelae of these events. NARCAN ® Nasal Spray is intended for immediate administration as emergency therapy in settings … Emergent BioSolutions does not control, influence or endorse this site, and the opinions, claims or comments expressed on this site should not be attributed to Emergent BioSolutions. PLEASE TURN O … The following serious adverse reactions are discussed elsewhere in the labeling:Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to the rates in the clinical studies of another drug and may not reflect the rates observed in practice.The following adverse reactions were observed in a Narcan Nasal Spray clinical study.In a pharmacokinetic study of 30 healthy adult volunteers exposed to one spray of Narcan Nasal Spray in one nostril or two sprays of Narcan Nasal Spray, one in each nostril, the most common adverse reactions were: increased blood pressure, constipation, toothache, muscle spasms, musculoskeletal pain, headache, nasal dryness, nasal edema, nasal congestion, nasal inflammation, rhinalgia, and xeroderma.The following adverse reactions have been identified primarily during post-approval use of naloxone hydrochloride in the post-operative setting. It is not known whether naloxone is excreted into human milk.Following a single intranasal administration of Narcan Nasal Spray (2 mg or 4 mg dose of naloxone hydrochloride), the mean plasma half-life of naloxone in healthy adults was approximately 1.85 (33% CV) hours and 2.08 (30% CV) hours; respectively, which was longer than that observed after administrations of a 0.4 mg naloxone hydrochloride intramuscular injection, where the half-life was 1.24 hours (26% CV). But many overdoses don’t reach medical care in time. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening, if not recognized, and should be treated according to protocols developed by neonatology experts In settings such as in neonates with known or suspected exposure to maternal opioid use, where it may be preferable to avoid the abrupt precipitation of opioid withdrawal symptoms, consider use of an alternate naloxone-containing product that can be dosed according to weight and titrated to effect.Also, in situations where the primary concern is for infants at risk for opioid overdose, consider whether the availability of alternate naloxone-containing products may be better suited than Narcan Nasal Spray.Geriatric patients have a greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.

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