No adjustment of dosage on the basis of gender is recommended.Reduced hepatic function - Citalopram oral clearance was reduced by 37% and half-life was doubled in patients with reduced hepatic function compared to normal subjects.
Energy expenditure is required.
The risk differences (drug vs. placebo), however, were relatively stable within age strata and across indications. Follow The drug dose or formulation may need to be modified to improve bioavailability.
Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy. If protein drugs with a molecular mass Perfusion (blood flow/gram of tissue) greatly affects capillary absorption of small molecules injected IM or sc.
Get medical help right away if you have any of these symptoms:have a heart problem including congenital long QT syndromeWhat should I tell my healthcare provider before taking Celexa? YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1800-FDA-1088.Keep Celexa and all medicines out of the reach of children.We comply with the HONcode standard for trustworthy health information - Decreased blood flow (eg, in shock) may lower the concentration gradient across the intestinal mucosa and reduce absorption by passive diffusion.Intestinal transit time can influence drug absorption, particularly for drugs that are absorbed by active transport (eg, B vitamins), that dissolve slowly (eg, To maximize adherence, clinicians should prescribe oral suspensions and chewable tablets for children < 8 years of age.
The single- and multiple-dose pharmacokinetics of citalopram are linear and dose-proportional in a dose range of 10-60 mg/day.
Like other antidepressants, Celexa should be introduced with care in patients with a history of seizure disorder.In studies in normal volunteers, Celexa in doses of 40 mg/day did not produce impairment of intellectual function or psychomotor performance. vary among trials, it is virtually impossible to distinguish a difference in drug effect from a difference due to one of the confounding factors just enumerated.Celexa (citalopram) is indicated for the treatment of depression.The efficacy of Celexa in the treatment of depression was established in 4-6 week, controlled trials of outpatients whose diagnosis corresponded most closely to the DSM-III and DSM-III-R category of major depressive disorder (see A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least five of the following nine symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt or suicidal ideation. The systemic clearance of citalopram was 330 mL/min, with approximately 20% of that due to renal clearance.Citalopram is metabolized to demethylcitalopram (DCT), didemethylcitalopram (DDCT), citalopram-N-oxide, and a deaminated propionic acid derivative. Do not use Celexa for a condition for which it was not prescribed.This Medication Guide summarizes the most important information about Celexa. Although no causal relationship to Celexa treatment has been found, the following adverse events have been reported to be temporally associated with Celexa treatment, and have not been described elsewhere in labeling: acute renal failure, akathisia, allergic reaction, anaphylaxis, angioedema, choreoathetosis, chest pain, delirium, dyskinesia, ecchymosis, epidermal necrolysis, erythema multiforme, gastrointestinal hemorrhage, angle closure glaucoma, grand mal convulsions, hemolytic anemia, hepatic necrosis, myoclonus, nystagmus, pancreatitis, priapism, prolactinemia, prothrombin decreased, QT prolonged, rhabdomyolysis, spontaneous abortion, thrombocytopenia, thrombosis, ventricular arrhythmia, torsade de pointes, and withdrawal syndrome.Animal studies suggest that the abuse liability of Celexa is low.
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