Patients treated concomitantly with Wellbutrin XL and such drugs may require increased doses of the drug Use extreme caution when coadministering Wellbutrin XL with other drugs that lower the seizure threshold (e.g., other bupropion products, antipsychotics, antidepressants, theophylline, or systemic corticosteroids). You can ask your healthcare provider or pharmacist for information about Wellbutrin XL that is written for health professionals.For more information about Wellbutrin XL, go to www.wellbutrinxl.com or call 1-800-321-4576.Inactive ingredients: ethylcellulose, glyceryl behenate, methacrylic acid copolymer dispersion, polyvinyl alcohol, polyethylene glycol, povidone, silicon dioxide, and triethyl citrate. In primate models assessing the positive reinforcing effects of psychoactive drugs, bupropion was self-administered intravenously. Seizures and/or cases of death have been reported when bupropion has been administered intranasally or by parenteral injection.Studies in rodents and primates demonstrated that bupropion exhibits some pharmacologic actions common to psychostimulants. The complete text of the Medication Guide is reprinted at the end of this document.Advise patients regarding the following issues and to alert their prescriber if these occur while taking Wellbutrin XL.Instruct patients, their families, and/or their caregivers to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down. - Die Nebenwirkungen (!!!) 0000006569 00000 n 1372 32

Fever, muscle rigidity, rhabdomyolysis, hypotension, stupor, coma, and respiratory failure have been reported mainly when bupropion was part of multiple drug overdoses.Although most patients recovered without sequelae, deaths associated with overdoses of bupropion alone have been reported in patients ingesting large doses of the drug. The risk of adverse reactions may be greater in patients with impaired renal function. doctor or pharmacist) as soon as possible about using a different or additional form of birth control. It may harm them.If you take a urine drug screening test, Wellbutrin XL may make the test result positive for amphetamines. Discontinue Wellbutrin XL if these reactions occur.Angle-Closure Glaucoma: The pupillary dilation that occurs following use of many antidepressant drugs including Wellbutrin XL may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy.Anaphylactoid/anaphylactic reactions have occurred during clinical trials with bupropion. 0000004004 00000 n W �hȁ"fhh���k �!�����M����::� F��� �X\C�@��,!g��9@�I H'�(%�^�HPI &� ���1HlH������"!�)@!�|h�>��j(�dFAA1�0��Э Ӂ4[X��B8��I &���}A�0�/A��:�T��H>�d]&(�� Why Are Dementia Patients Getting Risky Psychiatric Drugs? Prior to initiating Wellbutrin XL, screen patients for a history of bipolar disorder and the presence of risk factors for bipolar disorder (e.g., family history of bipolar disorder, suicide, or depression). However, the symptoms persisted in some cases; therefore, ongoing monitoring and supportive care should be provided until symptoms resolve.Wellbutrin XL can cause seizure. General information about the safe and effective use of Wellbutrin XL. Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure (e.g., iridectomy), if they are susceptible Educate patients that Wellbutrin XL contains the same active ingredient (bupropion) found in ZYBAN, which is used as an aid to smoking cessation treatment, and that Wellbutrin XL should not be used in combination with ZYBAN or any other medications that contain bupropion hydrochloride (such as Wellbutrin SR, the sustained-release formulation, Wellbutrin, the immediate-release formulation, and APLENZIN, a bupropion hydrobromide formulation). You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medications, or sedatives. The tablets are printed with edible black ink.Wellbutrin XL is a registered trademark of GlaxoSmithKline LLC used under license.APLENZIN is a trademark of Bausch Health Companies Inc. or its affiliates.All other product/brand names are the trademarks of the respective owners.© 2020 Bausch Health Companies Inc. or its affiliatesThis Medication Guide has been approved by the U.S. Food and Drug Administration.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

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