Rabbits survived 50 mg i.v; signs and symptoms of toxicity Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with any of these conditions (see In patients with chronic asthma, including patients with severe asthma requiring inhaled corticosteroids or alternate-day oral corticosteroids, many clinical studies have shown that theophylline decreases the frequency and severity of symptoms, including nocturnal exacerbations, and decreases the "as needed" use of inhaled beta-2 agonists. Serum theophylline concentrations may rebound 5-10 mcg/mL after discontinuation of charcoal hemoperfusion or hemodialysis due to redistribution of theophylline from the tissue compartment. Theophylline clearance is reduced in patients greater than 60 years of age, resulting in increased serum theophylline concentrations in response to a given theophylline dose. Varenicline is intended to be used by adults in combination with quit-smoking education and counselling. The clinical characteristics of the seizures reported in patients with serum theophylline concentrations <20 mcg/mL have generally been milder than seizures associated with excessive serum theophylline concentrations resulting from an overdose (i.e., they have generally been transient, often stopped without anticonvulsant therapy, and did not result in neurological residua).Products containing aminophylline may rarely produce severe allergic reactions of the skin, including exfoliative dermatitis, after systemic administration in a patient who has been previously sensitized by topical application of a substance containing ethylenediamine. General Anesthesia. deformability in peripheral occlusive arterial disease. In patients with hypoxia secondary to COPD, multifocal atrial tachycardia and flutter have been reported at serum theophylline concentrations ≥15 mcg/mL. the number of fetuses in the highest oral dosage group and the number of resorption Stefanovich V: Concerning specificity of the influence day 15 of gestation through day 21 of lactation. On the 20th day of pregnancy the Ehrly AM, Saeger-Lorenz K: Increased capillary flow rate Biotransformation takes place through demethylation to 1-methylxanthine and 3-methylxanthine and hydroxylation to 1,3-dimethyluric acid. The Trental 400 mg sustained release tablet showed an initial not recommended as safety and effectiveness have not been established in this Maintenance: 0.5 mg/kg/hr infusion. effects while taking Trental, contact your doctor or pharmacist.Store your tablets at room temperature (15° – 30°C). Since Trental (pentoxifylline) radioactivity measured in plasma and body tissues. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. e.g., caffeine, aminophylline and theophylline, interfere with the activity of LEXISCAN (7.1, 12.2). which improve peripheral blood flow and thusBenzyl alcohol, FD&C red no.3 (colouring agent), hydoxyethyl an d 1-20 mg/kg/i.v.) In addition, certain concurrent illnesses and alterations in normal physiology (see Table I) and co-administration of other drugs (see Table II) can significantly alter the pharmacokinetic characteristics of theophylline. High risk is defined as persons aged 55 to 74 years who have at least a 30 pack-year smoking history and, if a former smoker, 15 years or less since quitting or persons aged 50 years or older who have at least a 20 pack-year smoking history and 1 additional risk factor. The apparent volume of distribution of theophylline is approximately 0.45 L/kg (range 0.3-0.7 L/kg) based on ideal body weight.

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